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FLASH GENE
Symbol UTF1 contributors: mlc - updated : 15-12-2007
HGNC name undifferentiated embryonic cell transcription factor 1
HGNC id 12634
Location 10q26      Physical location : 135.043.777 - 135.045.061
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure
  • four GC boxes, but no TATA box in the 5'-flanking region
  • multiple transcription start sites
    • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1157 - 341 - Deloukas (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text pluripotent embryonic stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two highly conserved domain CD1 and CD2, independently able to bind to TATA-binding protein complex
  • a leucine zipper in CD2
    • HOMOLOGY
    interspecies homolog to murine undifferentiated embryonic cell transcription factor 1(from the F9 teratocarcinoma cell line)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • potentiating ATF-2 (activating transcription factor)-2 activity
  • displaying many of the hallmark characteristics expected for a tissue-specific transcriptional coactivator that works in early embryogenesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein Tata binding protein complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS