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FLASH GENE
Symbol USP6NL contributors: - updated : 20-09-2004
HGNC name USP6 N-terminal like
HGNC id 16858
Location 10p13      Physical location : 11.502.508 - 11.653.679
Synonym name related to the N terminus of tre
Synonym symbol(s) RNTRE, KIAA0019, TRE2NL
DNA
TYPE functioning gene
STRUCTURE 151.00 kb     0 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC389936 10 similar to proline-rich proteoglycan 2 LOC389937 10 similar to heat shock protein 90 beta LOC389938 10 similar to SI:dZ211O13.2 (novel protein) CUGBP2 10p13-p14 CUG triplet repeat, RNA binding protein 2 USP6NL 10p13 USP6 N-terminal like ECHDC3 10p14 enoyl Coenzyme A hydratase domain containing 3 C10orf47 10p14 chromosome 10 open reading frame 47 UPF2 10p14-p13 UPF2 regulator of nonsense transcripts homolog (yeast) DHTKD1 10p14 dehydrogenase E1 and transketolase domain containing 1 SEC61A2 10p14 dehydrogenase E1 and transketolase domain containing 1 NUDT5 10p14-p13 nudix (nucleoside diphosphate linked moiety X)-type motif 5 C10orf7 10p13 chromosome 10 open reading frame 7 CAMK1D 10p13 calcium/calmodulin-dependent protein kinase ID DKFZP761F241 10p14 hypothetical protein DKFZp761F241 LOC389939 10 similar to ribosomal protein L5 OPTN 10p14 optineurin MCM10 10p13 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) LOC221044 10p14 hypothetical protein BC018068 PHYH 10p15-p14 phytanoyl-CoA hydroxylase (Refsum disease) SEPHS1 10p14 selenophosphate synthetase 1 C10orf30 10p14 chromosome 10 open reading frame 30 PRPF18 10p12.33 PRP18 pre-mRNA processing factor 18 homolog (yeast) FLJ10210
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Usp6nl
homolog to rattus LOC291309
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • Rab5-specific GTPase activating activity
  • inhibits internalization of EGFR when complexed with EPS8
  • critical for macropinocytosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with EPS8
  • interacts with F-actin and actinin-4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS