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FLASH GENE
Symbol USP6NL contributors: - updated : 20-09-2004
HGNC name USP6 N-terminal like
HGNC id 16858
Location 10p13      Physical location : 11.502.508 - 11.653.679
Synonym name related to the N terminus of tre
Synonym symbol(s) RNTRE, KIAA0019, TRE2NL
DNA
TYPE functioning gene
STRUCTURE 151.00 kb     0 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Usp6nl
homolog to rattus LOC291309
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • Rab5-specific GTPase activating activity
  • inhibits internalization of EGFR when complexed with EPS8
  • critical for macropinocytosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with EPS8
  • interacts with F-actin and actinin-4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS