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FLASH GENE
Symbol USP50 contributors: mct - updated : 09-09-2019
HGNC name ubiquitin specific protease 50
HGNC id 20079
Location 15q21.2      Physical location : 50.792.759 - 50.838.902
Synonym name
  • inactive ubiquitin-specific peptidase 50
  • ubiquitin specific protease 50
  • EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 46.10 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1353 - 334 - 2018 29101126
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains a UCH domain
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may have a peptidase activity
  • USP50 levels are increased during erythropoiesis
  • USP50 protein degradation is independent of the proteasomal and the lysosomal degradation systems
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • USP50 may act through a HSP90AA1-dependent mechanism to counteract CDC25B mitotic inducing activity and prevent WEE1 degradation
  • deubiquitinating enzyme USP50 binds to the PYCARD protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of PYCARD
  • USP50 may indirectly regulate XRCC6 protein stability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS