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FLASH GENE
Symbol USP47 contributors: mct - updated : 18-10-2014
HGNC name ubiquitin specific protease 47
HGNC id 20076
Location 11p15.3      Physical location : 11.862.969 - 11.980.870
Synonym symbol(s) FLJ20727, TRFP, DKFZp686C13257,
EC.number 3.4.19.12
DNA
TYPE functioning gene
STRUCTURE 117.90 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 7777 - 1287 - 2011 21362556
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate   
Urinarybladder    
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a UCH domain
HOMOLOGY
interspecies homolog to murine Usp47
homolog to rattus LOC308896
Homologene
FAMILY peptidase family c19
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • having an effect on position-effect variegation
  • may be involved in ubiquitin-dependent protein catabolism
  • major enzyme involved in deubiquitylation of the key DNA base excision repair DNA polymerase (Pol beta)
  • important role for USP47 in regulating DNA repair and maintaining genome integrity
  • USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing STUB1-mediated KATNA1 degradation
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both BTRC and FBXW11 bind specifically to USP47, and point mutations in the TRCP WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction
  • a novel beta-TTCP interactor, that regulates cell growth and survival, potentially providing a novel target for anticancer therapies
  • USP47 was identified as KATNA1-specific deubiquitinating enzyme for its stabilization
  • KIFC3 suppresses the ubiquitination and resultant degradation of CDH1 by recruiting USP47 to adherens junction (AJ), a process that may be involved in maintaining stable cell-cell adhesion in epithelial sheets
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS