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FLASH GENE
Symbol USP46 contributors: mct/npt - updated : 08-10-2017
HGNC name ubiquitin specific protease 46
HGNC id 20075
Location 4q12      Physical location : 53.457.128 - 53.525.502
Synonym name
  • deubiquitinating enzyme 46
  • ubiquitin-specific-processing protease 46
  • ubiquitin thioesterase 46
  • Synonym symbol(s) FLJ12552, FLJ14283, FLJ11850, FLJ39393
    EC.number 3.4.19.12
    DNA
    TYPE virus associated
    STRUCTURE 68.38 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 7981 - 366 - 2004 14715245
    9 - 8057 - 359 - 2004 14715245
    9 - 7930 - 354 - 2004 14715245
    10 - 8133 - 225 - 2004 14715245
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
     female systemuterus   
    cell lineage
    cell lines teratocarcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a UCH domain
  • HOMOLOGY
    interspecies homolog to murine Usp46
    homolog to rattus LOC289584
    intraspecies paralog to USP12
    Homologene
    FAMILY
  • peptidase family C19
  • USP12/USP46 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • tumor suppressor role of USP46 in promoting PHLPP1 expression and inhibiting AKT1 signaling in colon cancer
  • role of the DUB (deubiquitinating enzyme) USP46 in the nervous system
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WDR20 (WDR20, a WD40-repeat containing protein, is a common binding partner of WDR48, USP12, and USP46) (Kee 2010)
  • binds to PHLPP1 and directly removes the polyubiquitin chains from PHLPP1 in cells
  • WDR48 interacts with the USP46 fingers subdomain via a relatively small, highly polar surface on the top center of the WDR48 beta propeller
  • WDR48 is a WD40 repeat protein, which binds and activates three important deubiquitinating enzymes (DUBs), USP1, USP12 and USP46
  • cell & other
    REGULATION
    Other is regulated by two WD40-repeat (WDR) proteins, WDR48/UAF1 and WDR20
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS