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FLASH GENE
Symbol USP46 contributors: mct/npt - updated : 08-10-2014
HGNC name ubiquitin specific protease 46
HGNC id 20075
Location 4q12      Physical location : 53.457.128 - 53.525.502
Synonym name
  • deubiquitinating enzyme 46
  • ubiquitin-specific-processing protease 46
  • ubiquitin thioesterase 46
  • Synonym symbol(s) FLJ12552, FLJ14283, FLJ11850, FLJ39393
    EC.number 3.4.19.12
    DNA
    TYPE virus associated
    STRUCTURE 68.38 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391651 4 similar to SNAG1 LOC391652 4 similar to SNAG1 KIAA0276 4q12 similar to SNAG1 LOC339977 4q12 similar to Hypothetical protein MGC38937 SGCB 4q12 sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) LOC132671 4q12 LOC132671 USP46 4q12 ubiquitin specific protease 46 KIAA0114 4q12 KIAA0114 gene product FLJ12684 4q12 hypothetical protein FLJ12684 MGC2827 4q12 hypothetical protein MGC2827 STXBP1L1 FIP1L1 4q11-q12 FIP1 like 1 (S. cerevisiae) LNX 4q12 ligand of numb-protein X LOC391653 4 hypothetical gene supported by BC057822 CHIC2 4q11-q12 cysteine-rich hydrophobic domain 2 GSH-2 4q11-q12 homeobox protein GSH-2 PDGFRA 4q11-q12 platelet-derived growth factor receptor, alpha polypeptide LOC254938 4q12 hypothetical LOC254938 KIT 4q12 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KDR 4q12 kinase insert domain receptor (a type III receptor tyrosine kinase) FLJ13352 4q12 hypothetical protein FLJ13352 TPARL 4q12 TPA regulated locus CLOCK 4q12 clock homolog (mouse) GCPHLP 4q12 likely ortholog of mouse germ cell-specific phosphoducin-like protein Mgcphlp NMU 4q12 neuromedin U SEC3 FLJ13621 4q12 hypothetical protein FLJ13621 KIAA0635 4q12-q13.3 hypothetical protein FLJ13621 KIAA1211 4q12 KIAA1211 protein MRPL22P1 4q12 KIAA1211 protein NRPS998 4q12 2-aminoadipic 6-semialdehyde dehydrogenase PPAT 4q12 phosphoribosyl pyrophosphate amidotransferase PAICS 4q12 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase SRP72 1q32 signal recognition particle 72kDa LOC132946 4q12 similar to MGC69138 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 7981 - 366 - 2004 14715245
    9 - 8057 - 359 - 2004 14715245
    9 - 7930 - 354 - 2004 14715245
    10 - 8133 - 225 - 2004 14715245
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
     female systemuterus   
    cell lineage
    cell lines teratocarcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a UCH domain
  • HOMOLOGY
    interspecies homolog to murine Usp46
    homolog to rattus LOC289584
    Homologene
    FAMILY
  • peptidase family C19
  • USP12/USP46 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • tumor suppressor role of USP46 in promoting PHLPP1 expression and inhibiting AKT1 signaling in colon cancer
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WDR20 (WDR20, a WD40-repeat containing protein, is a common binding partner of WDR48, USP12, and USP46) (Kee 2010)
  • binds to PHLPP1 and directly removes the polyubiquitin chains from PHLPP1 in cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS