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FLASH GENE
Symbol USP44 contributors: mct - updated : 04-02-2015
HGNC name ubiquitin specific protease 44
HGNC id 20064
Location 12q22      Physical location : 95.910.888 - 95.945.263
Synonym symbol(s) FLJ14528
EC.number 3.1.2.15/ 3.4.19.12
DNA
TYPE functioning gene
STRUCTURE 34.93 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6 LOC387875 12 LOC387875 LOC283412 12q23.1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) METAP2 12q22 methionyl aminopeptidase 2 USP44 12q21.33 ubiquitin specific protease 44 NTN4 12q22-q23 netrin 4 SNRPF 12q21.33 small nuclear ribonucleoprotein polypeptide F FLJ40089 12q23.1 hypothetical protein FLJ40089 MGC35366 12q23.1 hypothetical protein MGC35366 HAL 12q22-q23.1 histidine ammonia-lyase LTA4H 12q22 leukotriene A4 hydrolase ELK3 12q22-q23.1 ELK3, ETS-domain protein (SRF accessory protein 2) PCTK2 12q23.1 PCTAIRE protein kinase 2 FLJ31514 12q23.1 hypothetical protein FLJ31514 FLJ44112 12q23.1 FLJ44112 protein LOC387876 12 LOC387876 LOC390352 12 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati NEDD1 12q22 neural precursor cell expressed, developmentally down-regulated 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4032 - 712 - 2004 14715245
6 - 3890 - 712 - 2004 14715245
6 - 4106 - 712 - 2004 14715245
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Mus musculus
 liver     Mus musculus
 stomach     Mus musculus
Endocrinepancreas     Mus musculus
Reproductivemale systemtestis   
Respiratorylung     Mus musculus
Skin/Tegumentskin     Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain
  • a conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes
  • HOMOLOGY
    interspecies homolog to rattus LOC314746
    Homologene
    FAMILY peptidase family c19
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • important role for USP44 in regulating CDC20-APC/C activity, suggesting that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemia
  • RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
  • inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry
  • regulated the mitotic checkpoint and prevented chromosome lagging
  • prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can cleave ubiquitin from ubiquitinated substrate
  • deubiquitinase USP44 is a negative regulator of H2B ubiquitylation, whose downregulation during ESC differentiation contributes to the increase in H2Bub1
  • USP44 implicated in negative regulation of the RNF8/RNF168 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis (
  • mice lacking Usp44 were prone to the development of spontaneous tumors, particularly in the lungs