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FLASH GENE
Symbol USP42 contributors: mct - updated : 08-11-2013
HGNC name ubiquitin specific protease 42
HGNC id 20068
Location 7p22.2      Physical location : 6.144.549 - 6.201.194
Synonym name
  • deubiquitinating enzyme 42
  • ubiquitin carboxyl-terminal hydrolase 42
    • Synonym symbol(s) FLJ12697
    EC.number 3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 56.65 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned N linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 5135 - 1316 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY peptidase family C19
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • can cleave ubiquitin from ubiquitinated substrates
  • function of USP42 is required to allow the rapid activation of p53-dependent transcription and a TP53-dependent cell-cycle arrest in response to stress
  • likely contributing to the repair and recovery of cells from mild or transient damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • USP42 forms a direct complex with TP53 and controls level of ubiquitination during the early phase of the response to a range of stress signals
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a DUB that interacts with and deubiquitinates TP53
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    of RUNX1 and USP42 in a cryptic t(7;21)(p22;q22) in acute myeloid leukemia (AML)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS