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FLASH GENE
Symbol USP4 contributors: mct/pgu - updated : 21-02-2012
HGNC name ubiquitin specific peptidase 4 (proto-oncogene)
HGNC id 12627
Location 3p21.31      Physical location : 49.314.576 - 49.377.536
Synonym name
  • ubiquitin specific protease 4 (proto-oncogene)
  • ubiquitin thioesterase 4
  • ubiquitous nuclear protein homolog
  • Synonym symbol(s) UNP, UNPH, MGC149848, MGC149849, UnpEL
    EC.number 3.1.2.15/ 3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 62.96 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC344651 3p21.31 hypothetical LOC344651 SLC26A6 3p21 solute carrier family 26, member 6 CELSR3 3p24.1-p21.2 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) AF3P21 3p21 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) IHPK2 3p21.31 inositol hexaphosphate kinase 2 PRKAR2A 3p21.3-p21.2 protein kinase, cAMP-dependent, regulatory, type II, alpha SLC25A20 3p21.31 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ARIH2 3p21.2-p21.3 ariadne homolog 2 (Drosophila) PH-4 3p21.31 hypoxia-inducible factor prolyl 4-hydroxylase WDR6 15q21 WD repeat domain 6 FLJ10496 3p21.31 hypothetical protein FLJ10496 DKFZP564J0123 3p21.31 nuclear protein E3-3 IMPDH2 3p21.2 IMP (inosine monophosphate) dehydrogenase 2 FLJ20259 3p21.31 FLJ20259 protein QARS 3p21.3-p21.2 glutaminyl-tRNA synthetase USP19 3p21.3-p14.2 ubiquitin specific protease 19 LAMB2 3p21.3-p21.2 laminin, beta 2 (laminin S) FLJ12800 3p21.31 hypothetical protein FLJ12800 MGC35097 3p21.31 hypothetical protein MGC35097 LOC339834 3p21.31 hypothetical protein LOC339834 FLJ43654 3p21.31 FLJ43654 protein USP4 3p21.31 ubiquitin specific protease 4 (proto-oncogene) GPX1 3p21.2 glutathione peroxidase 1 ARHA 3p21.2 ras homolog gene family, member A TCTA 3p21 T-cell leukemia translocation altered gene AMT 3p21.2 aminomethyltransferase (glycine cleavage system protein T) NICN1 3p21.31 nicolin 1 DAG1 3p21.2-p21.1 dystroglycan 1 (dystrophin-associated glycoprotein 1) BSN 3p21.31 bassoon (presynaptic cytomatrix protein) APEH 3p21.3-p21.2 N-acylaminoacyl-peptide hydrolase MST1 3p21.31 macrophage stimulating 1 (hepatocyte growth factor-like) RNF123 3p24.3 ring finger protein 123 GMPPB 3p21.31 GDP-mannose pyrophosphorylase B IHPK1 3p21.31 inositol hexaphosphate kinase 1 LOC389117 3 similar to mouse fat 1 cadherin LOC389118 3 similar to VLLR9392 LOC389119 3 similar to RIKEN cDNA 6530418L21
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4120 110 963 ubiquitous 1998 9464533
  • UNPEL
  • extended long form, insertion 47 AAs
  • 21 - 3979 105 916 ubiquitous 1998 9464533
  • UNPES
  • shorter form
  • - - 1673 - 313 - 1998 9464533
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestine   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five highly conserved domains, domains I,II and III containing the expected catalytic triad Cys, Asp, His which defines cysteine proteases
  • HOMOLOGY
    interspecies homolog to murine Unp
    Homologene
    FAMILY
  • deubiquitin family
  • peptidase C19 family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text principally expressed in cytosol
    basic FUNCTION
  • functions as a deubiquitinating enzyme
  • modulation of USP4 expression may provide a new means to interfere with canonical Wnt signalling in a variety of physiological and pathological conditions
  • having a role in spliceosome regulation
  • serves as a critical control to downregulate TNF-induced NFKB activation through deubiquitinating MAP3K7
  • deubiquitinase targeting TRAF2 and TRAF6 for deubiquitination
  • negative regulator of TNF- and IL1B-induced cancer cell migration
  • USP4 and USP15 extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • colocalizes with the unubiquitinated form of TRIM21 to the cytoplasmic rod-like structures, where it keeps TRIM21 unubiquitinated
  • deubiquitinating PRPF3
  • interacting with ADORA2A
  • important regulator of TP53
  • interacts directly with and deubiquitinates HUWE1, leading to the stabilization of HUWE1 and subsequent reduction of TP53 levels
  • deubiquitinase for MAP3K7
  • USP4 is an enzyme that removes ubiquitin from PDPK1 in and co-localizes with PDPK1 at the plasma membrane when the two proteins are overexpressed, indicating direct deubiquitination
  • interacts with the PSMD11 subunit of the proteasome via an internal ubiquitin-like (UBL) domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in small cell and adenocarcinoma of lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS