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FLASH GENE
Symbol USP39 contributors: mct - updated : 03-05-2011
HGNC name ubiquitin specific protease 39
HGNC id 20071
Location 2p11.2      Physical location : 85.843.282 - 85.876.405
Synonym name SnRNP assembly defective 1 homolog
Synonym symbol(s) SAD1, CGI-21, HSPC332, MGC75069, SNRNP65
DNA
TYPE functioning gene
STRUCTURE 33.12 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ37357 2p11.2 hypothetical protein FLJ37357 LOC200383 2p11.2 similar to Dynein heavy chain at 16F FLJ23529 2p11.2 hypothetical protein FLJ23529 LOC129293 2p11.2 hypothetical protein LOC129293 TMSB10 2p11.2 thymosin, beta 10 KCMF1 2p11.2 potassium channel modulatory factor 1 LOC391388 2 hypothetical gene supported by AJ238095; NM_014463 TCF7L1 2p11.2 transcription factor 7-like 1 (T-cell specific, HMG-box) LOC388966 2 similar to hypothetical protein FLJ20296 TGOLN2 2p11.2 trans-golgi network protein 2 LOC388967 2 LOC388967 LOC388968 2 similar to Phosphatidylethanolamine-binding protein (PEBP) (Prostatic binding protein) (HCNPpp) (Neuropolypeptide h3) (Raf kinase inhibitor protein) (RKIP) FLJ20296 2p11.2 hypothetical protein FLJ20296 FLJ21977 2p11.2 hypothetical protein FLJ21977 CAPG 2cen-q24 capping protein (actin filament), gelsolin-like LOC284948 2p11.2 similar to B-cell linker; B cell linker protein MAT2A 2p11.2 methionine adenosyltransferase II, alpha GGCX 2p12 gamma-glutamyl carboxylase VAMP8 2p11.2-p11.1 vesicle-associated membrane protein 8 (endobrevin) VAMP5 2p11.2 vesicle-associated membrane protein 5 (myobrevin) LOC51255 2p11.2 hypothetical protein LOC51255 FLJ90024 2p11.2 fasting-inducible integral membrane protein TM6P1 LOC388969 2 LOC388969 USP39 2p11.2 ubiquitin specific protease 39 SFTPB 2p12-p11.2 surfactant, pulmonary-associated protein B GNLY 2p12-q11 granulysin HATH6 SIAT9 2p11.2 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) POLR1A 2p11.2 polymerase (RNA) 1 polypeptide A, 194kDa FLJ20758 2p11.2 FLJ20758 protein IMMT 2p11.2 inner membrane protein, mitochondrial (mitofilin) MRPL35 2p11.2 mitochondrial ribosomal protein L35 FLJ13110 2p11.2 hypothetical protein FLJ13110 JMJD1 2p11.2 jumonji domain containing 1 NEDF 2p24.3-p24.1 neuroendocrine differentiation factor RNF103 2p11.2 ring finger protein 103 FLJ13910 2p11.2 hypothetical protein FLJ13910
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2234 - 565 - 2008 18728397
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a UCH domain
  • an ubiquitin-protease domain
  • HOMOLOGY
    interspecies homolog to murine Usp39
    homolog to rattus LOC297336
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • pre mRNA splicing factor activity
  • also involved in ubiquitin dependent protein catabolism
  • required to maintain the spindle checkpoint and support successful cytokinesis
  • involved in splicing of Aurora B and other mRNAs that are essential for proper spindle checkpoint function
  • CELLULAR PROCESS nucleotide, RNA splicing
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of RNA splicing machinery
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • zebrafish usp39 mutants exhibit microcephaly and adenohypophyseal cell lineage expansion without apparent changes in major hypothalamic hormonal and regulatory signals