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FLASH GENE
Symbol USP38 contributors: mct - updated : 01-12-2020
HGNC name ubiquitin specific protease 38
HGNC id 20067
Location 4q31.21      Physical location : 144.106.069 - 144.143.140
Synonym symbol(s) KIAA1891, HP43.8KD
EC.number 3.1.2.15/3.4.19.12
DNA
TYPE functioning gene
STRUCTURE 39.51 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 7197 - 587 - 2004 14715245
9 - 4123 - 1004 - 2004 14715245
10 - 7081 - 1042 - 2004 14715245
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Endocrineadrenal gland    
Nervousbrain    
Reproductivemale systemprostate   
 male systemtestis   
Urinarybladder    
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a UCH domain
HOMOLOGY
interspecies homolog to murine Usp38
homolog to rattus LOC307764
Homologene
FAMILY peptidase family c19
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • critical role of USP38 in modulating genome integrity and cancer cell resistance to genotoxic insults by deubiquitinating HDAC1 and regulating its deacetylation activity
  • tumor suppressor role of USP38 in colorectal cancer via inhibiting cancer stem cell populations
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • USP38 regulates TBK1 ubiquitination through the NLRP4 signalosome
  • USP38 is an KDM1A-specific deubiquitinase that affects cellular physiology through interacting with kDM1A
  • USP38 is involved in the DNA damage response (DDR) by regulating the activity of HDAC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS