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FLASH GENE
Symbol USP37 contributors: mct - updated : 14-01-2012
HGNC name ubiquitin specific protease 37
HGNC id 20063
Location 2q35      Physical location : 219.314.973 - 219.433.084
Synonym symbol(s) KIAA1594
EC.number 3.1.2.15/ 3.4.19.12
DNA
TYPE functioning gene
STRUCTURE 118.11 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ46536 2q35 FLJ46536 protein IL8RB 2q35 interleukin 8 receptor, beta IL8RA 2q35 interleukin 8 receptor, alpha ARPC2 13q12-q13 actin related protein 2/3 complex, subunit 2, 34kDa GPBAR1 2q36.1 G protein-coupled bile acid receptor 1 AAMP 2q36.1 angio-associated, migratory cell protein MR-1 2q35 myofibrillogenesis regulator 1 PP1201 2p24.3-p24.1 PP1201 protein MGC50811 2q35 hypothetical gene supported by BC052750 SLC11A1 2q35 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 CTDSP1 2q35 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 VIL1 2q35 villin 1 USP37 2q35 ubiquitin specific protease 37 RQCD1 2q36.1 RCD1 required for cell differentiation1 homolog (S. pombe) PLCD4 2q35 phospholipase C, delta 4 ZNF142 2q34-q35 zinc finger protein 142 (clone pHZ-49) BCS1L 2q33 BCS1-like (yeast) RNF25 2q36.1 ring finger protein 25 STK36 2q35 serine/threonine kinase 36 (fused homolog, Drosophila) KIAA0173 2p24.3-p24.1 serine/threonine kinase 36 (fused homolog, Drosophila) CYP27A1 2q35-q36 cytochrome P450, family 27, subfamily A, polypeptide 1 PRKAG3 2q35 protein kinase, AMP-activated, gamma 3 non-catalytic subunit LOC391484 2 similar to 60S ribosomal protein L23a WNT6 2q35 wingless-type MMTV integration site family, member 6 WNT10A 2q35 wingless-type MMTV integration site family, member 10A LOC391485 2 similar to cytokeratin 8 CDK5R2 2q35 cyclin-dependent kinase 5, regulatory subunit 2 (p39) HSRNAFEV 2q33 cyclin-dependent kinase 5, regulatory subunit 2 (p39) CRYBA2 2q34-q36 crystallin, beta A2 DKFZp434O0527 2q36.1 hypothetical protein DKFZp434O0527
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 8032 - 979 - 2004 14715245
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Nervousbrain   highly
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain of USP37 required for the ZBTB16/RARA interaction and protein regulation
  • three ubiquitin-interacting motif (UIM) repeats
  • HOMOLOGY
    interspecies homolog to murine 4932415L06Rik
    homolog to rattus LOC316522
    Homologene
    FAMILY peptidase family c19
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • inactive in mitosis because it was no longer phosphorylated by CDK2
  • gatekeeper of APC/C-mediated ubiquitination of cyclin A
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds CDH1 and removes degradative polyubiquitin from cyclin A
  • USP37 interacted with ZBTB16/RARA through the PLZF moiety and sustained ZBTB16/RARA steady state levels
  • cell & other
    REGULATION
    induced by E2F transcription factors in G1, peaked at G1/S, and was degraded in late mitosis
    Phosphorylated by CDK2 that stimulated its full activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS