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FLASH GENE
Symbol USP36 contributors: mct/npt - updated : 26-05-2010
HGNC name ubiquitin specific protease 36
HGNC id 20062
Location 17q25.3      Physical location : 76.792.966 - 76.836.969
Synonym name
  • deubiquitinating enzyme 1
  • ubiquitin thioesterase 36
  • deubiquitinating enzyme 36
  • Synonym symbol(s) KIAA1453, FLJ12851, DUB1
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 44.57 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EVER1 17q25.3 epidermodysplasia verruciformis 1 EVER2 17q25.3 epidermodysplasia verruciformis 2 EIF5AP2 17q25 eukaryotic translation initiation factor 5A pseudogene 2 SYNGR2 17q25.3 synaptogyrin 2 TK1 17q25.1 thymidine kinase 1, soluble LOC125061 BIRC5 17q25 baculoviral IAP repeat-containing 5 (survivin) LOC283999 17q25.3 hypothetical protein LOC283999 LOC390816 17 similar to RIKEN cDNA 1300017K07 SOCS3 17q25.3 suppressor of cytokine signaling 3 LOC388421 17 LOC388421 PGS1 17q25.3 phosphatidylglycerophosphate synthase FLJ40457 17q25.3 hypothetical protein FLJ40457 LOC284120 17q25.3 hypothetical LOC284120 PSCD1 17q25-qter pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) USP36 17q25.3 ubiquitin specific protease 36 TIMP2 17q25..3 tissue inhibitor of metalloproteinase 2 LGALS3BP 17q25.2-q25.3 lectin, galactoside-binding, soluble, 3 binding protein SHAPY 17q25.3 Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase C1QTNF1 17q25.2 C1q and tumor necrosis factor related protein 1 LOC388422 17 LOC388422 FLJ21865 17q25.3 endo-beta-N-acetylglucosaminidase LOC339162 17q25.3 similar to ataxin 2-binding protein 1 isoform 2; hexaribonucleotide binding protein 1 LOC388423 17 LOC388423
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 5234 - 1123 - Endo (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
     spinal cord    
    Reproductivefemale systemovary   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a UCH domain
  • a PEST motif
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase family c19
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text localized to nucleoli via the C-terminal region, which contains basic amino acid stretches (Endo 2009)
    basic FUNCTION
  • having growth-suppressing activity
  • have a deubiquitinating (DUB) enzyme activity (Kim 2005)
  • inducing arrest in G1 phase upon controlled expression
  • deubiquitylating enzyme, that regulates nucleolar activity in mammalian cells (Endo 2009)
  • plays a crucial role in regulating the structure and function of nucleoli (Endo 2009)
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by deubiquitylating various nucleolar substrate proteins including NPM1 and FBL, USP36 plays a crucial role in regulating the structure and function of nucleoli
  • FBL is a USP36 substrate protein in nucleoli (pMID: 19679658)
  • regulates the protein stability of SOD2
  • cell & other
    REGULATION
    induced by interleukin-3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients (Li 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS