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FLASH GENE
Symbol USP36 contributors: mct/npt - updated : 28-04-2020
HGNC name ubiquitin specific protease 36
HGNC id 20062
Location 17q25.3      Physical location : 76.792.966 - 76.836.969
Synonym name
  • deubiquitinating enzyme 1
  • ubiquitin thioesterase 36
  • deubiquitinating enzyme 36
  • Synonym symbol(s) KIAA1453, FLJ12851, DUB1
    EC.number 3.1.2.15/3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 53.46 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 5951 - 1123 - 2018 29274341
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
     spinal cord    
    Reproductivefemale systemovary   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a UCH domain
  • a PEST motif
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase family c19
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    text localized to nucleoli via the C-terminal region, which contains basic amino acid stretches (Endo 2009)
    basic FUNCTION
  • having growth-suppressing activity
  • have a deubiquitinating (DUB) enzyme activity (Kim 2005)
  • inducing arrest in G1 phase upon controlled expression
  • deubiquitylating enzyme, that regulates nucleolar activity in mammalian cells (Endo 2009)
  • plays a crucial role in regulating the structure and function of nucleoli (Endo 2009)
  • controls selective autophagy activation
  • is a novel H2B deubiquitinase which shed light on its additional functions in regulating gene expression
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by deubiquitylating various nucleolar substrate proteins including NPM1 and FBL, USP36 plays a crucial role in regulating the structure and function of nucleoli
  • FBL is a USP36 substrate protein in nucleoli
  • regulates the protein stability of SOD2
  • USP36 function in SQSTM1-dependent selective autophagy
  • nucleolar USP36 is a novel MYC deubiquitinase that controls the end-point of MYC degradation pathway in the nucleolus
  • USP36 binds to and regulates the actions of NEDD4L over different substrates affecting their expression and functions
  • USP36 regulates PPME1 as a DUB and participates in the ERK and Akt signaling pathways.
  • important role of MELK and USP36 in mediating EZH2 stability in natural killer/T-cell lymphoma (NKTL)
  • USP36 is regulator for the PRKN-dependent mitophagy at least in part via the BECN1-ATG14 pathway
  • cell & other
    REGULATION
    induced by interleukin-3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients (Li 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS