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FLASH GENE
Symbol USP34 contributors: mct - updated : 28-08-2013
HGNC name ubiquitin specific peptidase 34
HGNC id 20066
Location 2p15      Physical location : 61.414.590 - 61.697.849
Synonym name
  • ubiquitin specific protease 34
  • KIAA0570 gene product
  • deubiquitinating enzyme 34
    • Synonym symbol(s) KIAA0729, KIAA0570, FLJ43910, MGC104459
    EC.number 3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 283.26 kb     80 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    80 - 11326 - 3546 - 2011 21383061
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase C19 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • ubiquitin thiolesterase activity
  • functions downstream of the CTNNB destruction complex to control the stability of axin and opposes its tankyrase-dependent ubiquitination
  • regulates axin stability and Wnt/CTNNB signaling
  • new player involved in the fine-tuning of NFKB1 upon TCR stimulation
  • promotes potentially a feed-forward loop to enforce ubiquitin signaling at DSBs and highlight critical roles of ubiquitin dynamics in genome stability maintenance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functions downstream of the CTNNB1 destruction complex to control the stability of AXIN1 and opposes its TNKS-dependent ubiquitination
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS