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FLASH GENE
Symbol USP33 contributors: mct/npt - updated : 13-03-2018
HGNC name ubiquitin specific peptidase 33
HGNC id 20059
Location 1p31.1      Physical location : 78.161.675 - 78.225.537
Synonym name
  • ubiquitin carboxyterminal hydrolase family 2
  • VHL-interacting deubiquitinating enzyme 1
  • ubiquitin specific protease 33
  • ubiquitin thioesterase 33
  • Synonym symbol(s) KIAA1097, VDU1, MGC16868
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 63.89 kb     24 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC22773 1p31.1 hypothetical protein MGC22773 FPGT 1p31.1 fucose-1-phosphate guanylyltransferase CARK DKFZp547I048 1p31.1 hypothetical protein DKFZp547I048 CRYZ 1p31-p22 crystallin, zeta (quinone reductase) LOC388640 1 similar to crystallin, zeta; NADPH:quinone reductase LOC127253 1p31.1 hypothetical protein BC009514 LOC148864 1p31.1 similar to LIM homeo domain transcription factor MGC34032 1p31.1 hypothetical protein MGC34032 LOC388641 1 LOC388641 LOC343221 1p31.1 similar to KIAA0433 protein ACADM 1p31 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain DLSTP 1p31 dihydrolipoamide S-succinyltransferase pseudogene (E2 component of 2-oxo-glutarate complex) RABGGTB 1p31 Rab geranylgeranyltransferase, beta subunit MSH4 1p31 mutS homolog 4 (E. coli) ASB17 1p31.1 ankyrin repeat and SOCS box-containing 17 SIAT7C 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C LOC388642 1 similar to Triosephosphate isomerase (TIM) LOC388643 1 LOC388643 SIAT7E 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E LOC256483 1p31.1 hypothetical LOC256483 PIGK 1p31.1 phosphatidylinositol glycan, class K AK5 1p31 adenylate kinase 5 DKFZP564I052 USP33 1p31.1 ubiquitin specific protease 33 FLJ35093 1p31.1 FLJ35093 protein LOC91624 FUBP1 1p31.1 far upstream element (FUSE) binding protein 1 DNAJB4 1p31.1 DnaJ (Hsp40) homolog, subfamily B, member 4 LOC339425 1p31.1 similar to Nit protein 2 GIPC2 1p31.1 PDZ domain protein GIPC2 LOC388644 1 hypothetical gene supported by AK091757 PTGFR 1p31.1 prostaglandin F receptor (FP) C1orf29 1p31.1 chromosome 1 open reading frame 29 IFI44 1p31.1 interferon-induced protein 44 LOC343295 1p31.1 similar to Nuclear protein SkiP (Ski-interacting protein) (SNW1 protein) (Nuclear receptor coactivator NCoA-62) ELTD1 1p33-p32 EGF, latrophilin and seven transmembrane domain containing 1 LOC149050 1p31.1 similar to phosphoserine aminotransferase isoform 1 LOC343296 1p31.1 similar to Alcohol dehydrogenase class III chi chain (Glutathione-dependent formaldehyde dehydrogenase) (FDH) LOC391049 1 similar to Rda288-prov protein COX6A1P 1p31.1 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene LOC391050 1 similar to ribosomal protein L7 LOC343301 1p31.1 similar to ribosomal protein L10a
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4551 107 942 - 2011 21801292
  • USP33 T1
  • 24 - 4372 103 911 . insert within the catalytic domain, required for association with the endoplasmic reticulum 2011 21801292
  • USP33 T2
  • 23 - 2956 - 828 marked accumulation at the Golgi apparatus 2011 21801292
  • second insert is required for membrane association, but can be alternatively spliced (variant 3) to excise eight amino acids, which otherwise suppress Golgi localization
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ZnF UBP domain
  • a protein module found in many proteins in the ubiquitin-proteasome system, that does not bind to ubiquitin (Allen 2007)
  • HOMOLOGY
    interspecies homolog to murine Vdu1
    Homologene
    FAMILY
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • would be involved in ubiquitin-dependent protein catabolism
  • deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein and also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase (Allen 2007)
  • player in Slit-Robo signaling in cancer cell migration and required for Slit responsiveness in breast cancer cells (Yuasa-Kawada 2009)
  • required for Slit-induced Robo1 relocation to the plasma membrane (Yuasa-Kawada 2009)
  • role in vertebrate commissural axon guidance and in SLIT1 signaling (Yuasa-Kawada 2009)
  • required for SLIT1 responsiveness of commissural neurons (Yuasa-Kawada 2009)
  • USP33 and USP20 coordinate ADRB2 recycling and resensitization
  • is a deubiquitinase that has been associated with a variety of physiological events
  • USP33 potently and specifically deubiquitinates CCP110, but not other cyclin-F substrates
  • is a previously unknown tumor-suppressing gene for colorectal cancer (CRC) by mediating the inhibitory function of Slit-Robo signaling on CRC cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VHL (target for ubiquitination and degradation by pVHL E3 ligase)
  • interacting with SELENBP1 (Jeong 2009)
  • interacts with ROBO1 and is required for Slit-induced ROBO1 redistribution to the plasma membrane without affecting the total ROBO1 protein level (Yuasa-Kawada 2009)
  • USP33 interacts with CCP110 and localizes to centrioles primarily in S and G2/M phases, the periods during which centrioles duplicate and elongate
  • HERC2, a HECT domain-containing E3 ligase, as being responsible for polyubiquitination of USP33
  • ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2
  • BTRC interacted with USP33 independently of the classic binding motif for BTRC, and mediated USP33 degradation via the ubiquitin proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple cohorts of lung cancer patients and low expression of USP33 is associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • independent prognostic biomarker for papillary thyroid carcinoma (PTC), low USP33 expression indicated high recurrence risk
  • potential value of USP33 as an independent prognostic marker of colorectal cancer (CRC)
  • Therapy target
    ANIMAL & CELL MODELS