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FLASH GENE
Symbol USP26 contributors: mct - updated : 25-08-2008
HGNC name ubiquitin specific protease 26
HGNC id 13485
Location Xq26.2      Physical location : 132.159.507 - 132.162.300
Synonym symbol(s) MGC120066, MGC120067,MGC120068
EC.number 3.1.2.15
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2794 - 913 - Christensen (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemvagina  highly
 male systemtestis  specific
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
His and Cys domains conserved among deubiquitinating enzymes
HOMOLOGY
Homologene
FAMILY ubiquitin carboxyl terminal hydrolase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
intracellular,nuclear envelope,pore
basic FUNCTION
  • involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to male infertility (minor role)
    Variant & Polymorphism other 494T>C increases the risk of male infertlity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS