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FLASH GENE
Symbol USP25 contributors: mct - updated : 30-01-2018
HGNC name ubiquitin specific peptidase 25
HGNC id 12624
Location 21q21.1      Physical location : 17.102.495 - 17.252.377
Synonym name
  • ubiquitin-specific protease on chromosome 21
  • ubiquitin thioesterase 25
  • ubiquitin carboxyl-terminal hydrolase 25
  • Synonym symbol(s) USP21
    EC.number 3.1.2.15/3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 149.88 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • IRF7 directly binds to the two conserved IRF binding sites on the USP25 promoter to drive transcription of USP25, and mutation of these two sites abolished Sendai virus-induced IRF7-mediated activation of the USP25 promoter
  • MAPPING cloned Y linked N status confirmed
    Physical map
    ANKRD21 21q11.2 ankyrin repeat domain 21 LOC391265 21 similar to cDNA sequence BC021523 LOC388810 21 hypothetical gene supported by AL834140 LOC343720 21q11.2 similar to fem-1 homolog a (C.elegans) TERF1P 21 telomeric repeat binding factor (NIMA-interacting) 1 pseudogene LOC391266 21 similar to h2-calponin CYP4F3LP 21p11 cytochrome P450, family 4, subfamily F, polypeptide 3-like pseudogene LOC391267 21 similar to SNAG1 LOC388812 21 similar to Ankyrin repeat domain protein 18A C21orf81 21q22.1 chromosome 21 open reading frame 81 LOC391268 21 similar to KIAA0685 protein LOC391269 21 similar to hypothetical protein DKFZp434A171 LOC375108 21q11.2 membrane-associated phospholipase A1 beta RBM11 21q11 RNA binding motif protein 11 ABCC13 21q11.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 13 STCH 21q11.2 stress 70 protein chaperone, microsome-associated, 60kDa SAMSN1 21q11 SAM domain, SH3 domain and nuclear localisation signals, 1 LOC388813 21 LOC388813 POLR2CP 21q11.2 polymerase (RNA) II (DNA directed) polypeptide C, pseudogene NRIP1 21q11.2 nuclear receptor interacting protein 1 LOC388814 21 LOC388814 HCP42 21q11.2 cytochrome c, somatic pseudogene USP25 21q11.2 ubiquitin specific protease 25 VDAC2P 21q11.2 voltage-dependent anion channel 2 pseudogene LOC388815 21 hypothetical gene supported by AF486622 LOC391270 21 similar to RIKEN cDNA F730108M23 gene CXADR 21q11.2 coxsackie virus and adenovirus receptor BTG3 21q11.2-q21.1 BTG family, member 3 C21orf91 21q21.1 chromosome 21 open reading frame 91
    RNA
    TRANSCRIPTS type messenger
    text two alternatively spliced isoforms (Valero)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 5450 129.9 1125 - 2017 28538147
    24 - 5240 122.2 1055 - 2017 28538147
    24 - 5336 125.75 1087 - 2017 28538147
    17 - 5001
    14 - 5240 - 651 - 2017 28538147
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
     stomach   highly
    Endocrinepancreas    
     thyroid   highly
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
     female systemplacenta  moderately
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text predominantly in umbilical cord, moderately in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal ubiquitin-binding region (UBR) contains one ubiquitin-associated domain, one small ubiquitin-like modifier (SUMO)-interacting motif and two UIM ubiquitin-interacting motifs
  • five highly conserved domains, domains I, II and IIIcontaining the expected catalytic triad Cys, Asp, His which defines cysteine proteases
  • secondary structure
  • a ~20-amino-acid alpha-helical stretch that binds to ubiquitin
  • HOMOLOGY
    interspecies homolog to rattus Usp25 (94.4 pc)
    homolog to murine Usp25 (94 pc)
    Homologene
    FAMILY
  • USP family of deubiquitinases
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome
  • acting as a cysteine-type peptidase
  • acting as an ubiquitin thiolesterase
  • is a negative regulator of the virus-triggered type I IFN signaling pathway
  • is likely a novel DUB negatively regulating virus-induced type I IFN production
  • positive feedback regulation of innate immune responses against RNA and DNA viruses by USP25
  • deubiquitinase that is involved in multiple biological processes
  • regulates WNT signaling by controlling the stability of TNKS, TNKS2
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between SYK and the ubiquitin-specific protease 25 (USP25)
  • counteracts ubiquitination of ERAD substrates by the ubiquitin ligase SYVN1, rescuing them from degradation by the proteasome
  • by inhibiting the degradation of TRAF3 during TLR4 activation, USP25 enables a balanced innate immune response
  • is a regulator of TLR signaling
  • APP interacts with USP25
  • USP25 is a positive regulator of WNT/CTNNB1 signaling
  • directly interacted with TNKS, TNKS2 to promote their deubiquitination and stabilization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Usp25 deficient mice were more susceptible to H5N1 or HSV-1 infection compared with the wild-type mice