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FLASH GENE
Symbol USP24 contributors: mct/npt - updated : 22 -09-200
HGNC name ubiquitin specific peptidase 24
HGNC id 12623
Location 1p32.3      Physical location : 55.532.032 - 55.681.039
Synonym name
  • ubiquitin specific protease 24
  • deubiquitinating enzyme 24
  • ubiquitin carboxyl-terminal hydrolase 24
  • Synonym symbol(s) KIAA1057, FLJ31309
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 148.73 kb     69 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D1S2661 - USP24 , D1S417 - D1S2442 - D1S2665 - D1S476 - cen
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    69 - 10087 - 2460 - Oliveira, Quesada (2004)
    also called USP24L
    - - 3865 - 309 - Strausberg, Quesada (2004)
    also called USP24S
    - - 5618 112 977 - Kikuno, Quesada (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • deubiquitin family
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26s proteasome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to late-onset Parkinson disease
    Variant & Polymorphism SNP SNP influencing age-at-onset in Parkinson disease, see PARK10 (Haugarvoll 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS