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FLASH GENE
Symbol USP22 contributors: mct/npt - updated : 01-06-2010
HGNC name ubiquitin specific protease 22
HGNC id 12621
Location 17p13.1      Physical location : 20.902.907 - 20.946.352
Synonym name
  • S.pombe ubiquitin carboxy terminal hydrolase
  • ubiquitin specific peptidase 3-like
  • deubiquitinating enzyme 22
  • ubiquitin carboxyl-terminal hydrolase 22
  • Synonym symbol(s) KIAA1063, USP3L
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 43.45 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - USP22 - cen - MAP2K6 - KCNJ16 - KCNJ2 - SOX9 - C17orf26 - SSTR2 - C17orf27 - qter
    Authors Bagheri-fam (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5220 60 525 - Zhang (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Nervousbrain   highly
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text pronounced expression of Usp22 during the early embryonic development, although its expression was not detectable in the gut, liver and heart (Lee 2006)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • have deubiquitinating enzyme activity (Lee 2006)
  • polycomb protein functioning as global transcriptional repressors by catalyzing the ubiquitylation of histone H2A (Zhang 2008)
  • H2A ubiquitin hydrolase USP22 is coordinately expressed with polycomb H2A ubiquitin ligases in order that the transcription of certain critical transforming genes be maintained in the face of the global repression mediated by polycomb (Zhang 2008)
  • recruited to specific genes by activators such as the Myc oncoprotein, where it is required for transcription (Zhang 2008)
  • with ATXN7L3, and ENY2 are required as cofactors for the full transcriptional activity by nuclear receptors (Zhao 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the human SAGA transcriptional cofactor complex (Zhang 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates cell proliferation by deubiquitinating the transcriptional regulator FUBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS