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FLASH GENE
Symbol USP20 contributors: mct - updated : 14-03-2018
HGNC name ubiquitin specific protease 20
HGNC id 12619
Location 9q34.11      Physical location : 132.597.695 - 132.644.107
Synonym name
  • related to chicken ubiquitin specific protease 41
  • pVHL-interacting deubiquitinating enzyme 2
  • linked to surfeit gene in Fugu rubripes homolog 3
    • Synonym symbol(s) KIAA1003, VDU2, LSFR3A, hVDU2
    EC.number 3.1.2.15/3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 46.42 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 4459 - 914 - 2015 25708858
    25 - 4538 - 914 - 2015 25708858
    26 - 4361 - 914 - 2015 25708858
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     nerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two DUSP domains
  • a UBP-type zinc finger
    • HOMOLOGY
    interspecies homolog to murine Usp20
    Homologene
    FAMILY
  • ubiquitin carboxyl-terminal hydrolase (UCH) family
  • peptidase family C19
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nuclear envelope
    basic FUNCTION
  • can specifically deubiquitinate and stabilize HIF1A and, therefore, increase expression of HIF-1alpha targeted genes, such as vascular endothelial growth factor (VEGF)
  • USP33 and USP20 coordinate ADRB2 recycling and resensitization
  • function of USP20 in genome maintenance and DNA repair
  • is critical for replication stress response
  • roles of USP18 and USP20 in mediating virus-triggered signaling
  • USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on MAPK6 expression
  • USP20 plays a crucial role in autophagy initiation by maintaining the basal expression level of ULK1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with HIF-1alpha
  • USP20 is a key negative regulator of TAX-induced NFKB1 signaling
  • regulates the reciprocal functions of ARRB2 in TLR4-promoted Nuclear Factor kappaB (NFKB) activation
  • function of HERC2/USP20 in coordinating CHEK1 activation by modulating CLSPN stability, which ultimately promotes genome stability and suppresses tumor growth
  • ubiquitination by the E3 ligase NEDD4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated ADRB2
  • USP20 is a novel MAPK6 regulator (USP20 interacts with and deubiquitinates MAPK6 both in vitro and in intact cells)
  • USP20 is a positive regulator of CLSPN and suppresses the malignant characteristics of gastric cancer cells
  • USP20 acts as a positive regulator of autophagy initiation through stabilizing ULK1
    • cell & other
    REGULATION
    Phosphorylated by ATR, resulting in disassociation of the E3 ubiquitin ligase HERC2 from USP20 and USP20 stabilization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    led to the inhibition of proliferation, G1-S cell cycle transition delay and autophagy activation
    tumoral     --over  
    in Gastric cancer predicted longer survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS