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FLASH GENE
Symbol USP2 contributors: mct - updated : 12-01-2013
HGNC name ubiquitin specific protease 2
HGNC id 12618
Location 11q23.3      Physical location : 119.225.925 - 119.252.436
Synonym symbol(s) UBP41, USP9
EC.number 3.4.19.12
DNA
TYPE functioning gene
STRUCTURE 26.51 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
BCL9L 11q23.3 B-cell CLL/lymphoma 9-like UPK2 11q23 uroplakin 2 LOC283150 11q23.3 hypothetical protein LOC283150 DLNB14 11q23.3 similar to DLNB14 RPS25 11q23.3 ribosomal protein S25 TRAPPC4 11q23.3 trafficking protein particle complex 4 SLC37A4 11q23.3 solute carrier family 37 (glycerol-6-phosphate transporter), member 4 HYOU1 11q23.1-q23.3 hypoxia up-regulated 1 VPS11 11q23 vacuolar protein sorting 11 (yeast) HMBS 11q23.3 hydroxymethylbilane synthase H2AFX 11q23.3 H2A histone family, member X DPAGT1 11q23.3 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) KIAA0285 11q23.3 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) MIZF 11q23.3 MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein ABCG4 11q23.3 ATP-binding cassette, sub-family G (WHITE), member 4 NOD9 11q23.3 NOD9 protein PDZK2 11q23.3 PDZ domain containing 2 LOC387812 11 LOC387812 CBL 11q23.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence MCAM 11q23.3 melanoma cell adhesion molecule RNF26 11q23 ring finger protein 26 C1QTNF5 11q23.3 C1q and tumor necrosis factor related protein 5 MFRP 11q23 membrane frizzled-related protein USP2 11q23.3 ubiquitin specific protease 2 LOC94105 11q22.3-q23 Thy-1 co-transcribed THY1 11q23.3 Thy-1 cell surface antigen LOC387813 11 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 PVRL1 11q23-q24 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2748 - 605 - 2012 22659130
  • USP2a
  • stabilizing fatty acid synthase (FAS), often overexpressed in biologically aggressive tumors(in prostate cancer)
  • USP2a and USP2c, two isoforms of the ubiquitin-specific protease USP2, cause cell death upon ectopic expression
  • 13 - 3013 45 396 . localized to peroxisomes in hepatocytes through a canonical peroxisome-targeting motif at its C-terminus 2012 22659130
  • USP2b, (USP2-45)
  • is a deubiquitinase that regulates hepatic gluconeogenesis and glucose metabolism
  • is in a complex with several clock components and regulates the stability and turnover of ARNTL, which in turn alters the expression of several PER/ARNTL controlled genes
  • 12 - 2933 - 362 - 2012 22659130
  • USP2c
  • USP2a and USP2c, two isoforms of the ubiquitin-specific protease USP2, cause cell death upon ectopic expression
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineparathyroid   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • having ubiquitin thiolesterase activity
  • having a direct proapoptotic activity additionally tightening the connection between apoptosis and the ubiquitin-proteasome system
  • implicated as a novel positive regulator of TNF-induced NFKB signaling and show that its expression is altered in tumor cells
  • de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN
  • potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation
  • role for the rhythmically-expressed deubiquitinating enzyme ubiquitin specific peptidase 2 (USP2) in clock function
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • new core component of the clock machinery and potential role for deubiquitination in the regulation of the circadian clock, both at the level of the core pacemaker and its response to external cues
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STUB1 and USP2 show antagonistic functions in the control of AIFM1-mediated cell death, and implicate the role of the enzymes as a switch for cells to live or die under stresses that cause truncated AIFM1 release
  • mediates mitotic progression by regulating the stability of Aurora-A
  • interacts with CRY1 and enhances its protein stability via deubiquitination upon serum shock
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a deletion of the Usp2 gene (Usp2 KO) display a longer free-running period of locomotor activity rhythms and altered responses of the clock to light