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FLASH GENE
Symbol USP17L2 contributors: SGE/npt - updated : 08-06-2010
HGNC name ubiquitin specific peptidase 17-like 2
HGNC id 34434
Location 8p23.1      Physical location : 11.994.676 - 11.996.269
Synonym name
  • ubiquitin carboxyl-terminal hydrolase
  • deubiquitinating enzyme 3
  • ubiquitin thioesterase 17-like protein 2
  • deubiquitinating enzyme 17-like protein 2
  • ubiquitin-specific-processing protease 17-like protein 2
  • Synonym symbol(s) DUB-3, DUB3
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 1.59 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1593 59 530 - Burrows (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine DUB-1A
    Homologene
    FAMILY
  • peptidase C19 family
  • USP17 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inducing arrest in G1 phase upon controlled expression
  • playing a role in the control of cell proliferation and survival
  • functioning in cell apoptosis
  • cleaves ubiquitin fusion protein substrates
  • stabilizing CDC25A by removing its polyubiquitin modifications and thus promoting oncogenic transformation (Pereg 2010)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interleukin-3
    Other up-regulated by IL4 and IL6
    immediate early gene induced and transiently expressed upon cytokine stimulation (Burrows 2004)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS