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FLASH GENE
Symbol USP16 contributors: mct/ - updated : 15-11-2014
HGNC name ubiquitin specific protease 16
HGNC id 12614
Location 21q21.3      Physical location : 30.396.937 - 30.426.805
Synonym name
  • deubiquitinating enzyme 16
  • ubiquitin carboxyl-terminal hydrolase 16
  • ubiquitin-specific processing protease
  • ubiquitin thiolesterase 16
  • Synonym symbol(s) UBP-M, MSTP039, UBPM
    EC.number 3.1.2.15, 3.4.19.12
    DNA
    TYPE functioning gene
    STRUCTURE 29.87 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2989 93 823 - 2007 17512543
    19 - 3052 93.6 823 - 2007 17512543
    18 - 2986 93.5 822 - 2007 17512543
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • BUZ/Znf-UBP domain is a protein module found in the cytoplasmic deacetylase HDAC6, E3 ubiquitin ligase BRAP2, and a subfamily of ubiquitin-specific proteases, requiring a C-terminal Gly-Gly motif for binding (BUZ domains recognize specific C-terminal sequences of proteins)
  • a coiled-coil domain
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase C19 family
  • USP16 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may deubiquitinate one or more critical proteins involved in the condensation of mitotic chromosomes, possibly acting selectively on histones H2A and H2B, the major ubiquitinated proteins of chromatin
  • major deubiquitinase for histone H2A (H2A deubiquitination by USP16 is a prerequisite for subsequent phosphorylation of Ser 10 of H3 and chromosome segregation when cells enter mitosis)
  • deubiquitination enzyme involved in chromatin remodelling and cell cycle progression
  • required for acute HIST2H2AC deubiquitylation and transcriptional derepression at double-strand breaks upon ATM inhibition
  • important role in antagonizing the self-renewal and/or senescence pathways in Down syndrome
  • USP16 and HIST2H2AA3 deubiquitination are critical regulators of embryonic stem cell (ESC) gene expression and differentiation
  • is a critical regulator of DNA damage response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates Hox gene expression through H2A deubiquitination
  • HERC2 interacts with the coiled-coil domain of USP16 through its C-terminal HECT domain
  • USP16 deubiquitinates PLK1, resulting in an enhanced interaction with kinetochore-localized proteins such as BUB1B, and thereby retains PLK1 on the kinetochores to promote proper chromosome alignment in early mitosis
  • cell & other
    REGULATION
    Phosphorylated by CDK1 (phosphorylated at S552 and CDK1 is the enzyme responsible for the phosphorylation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    cryptic inversion of chromosomal region 21q21-22 leading to break and fusion of RUNX1 to USP16, in chronic myelomonocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    mental retardationtrisomy 
    could serve as an attractive target to ameliorate some of the associated pathologies to Down syndrome
    ANIMAL & CELL MODELS