basic FUNCTION
| may deubiquitinate one or more critical proteins involved in the condensation of mitotic chromosomes, possibly acting selectively on histones H2A and H2B, the major ubiquitinated proteins of chromatin |
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major deubiquitinase for histone H2A (H2A deubiquitination by USP16 is a prerequisite for subsequent phosphorylation of Ser 10 of H3 and chromosome segregation when cells enter mitosis) |
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deubiquitination enzyme involved in chromatin remodelling and cell cycle progression |
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required for acute HIST2H2AC deubiquitylation and transcriptional derepression at double-strand breaks upon ATM inhibition |
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important role in antagonizing the self-renewal and/or senescence pathways in Down syndrome |
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USP16 and HIST2H2AA3 deubiquitination are critical regulators of embryonic stem cell (ESC) gene expression and differentiation |
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is a critical regulator of DNA damage response |