Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol USP13 contributors: mct - updated : 22-05-2013
HGNC name ubiquitin specific protease 13 (isopeptidase T-3)
HGNC id 12611
Location 3q26.33      Physical location : 179.370.932 - 179.507.187
Synonym name ubiquitin isopeptidase 3
Synonym symbol(s) ISOT3, IsoT-3
EC.number 3.1.2.15/ 3.4.19.12
DNA
TYPE like-sequence
SPECIAL FEATURE head to head
STRUCTURE 136.26 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 7933 - 863 - 1998 9841226
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 female systemuteruscervix highly
 male systemtestis   
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two UBA domains
  • an UBP-type zinc finger
  • an Ub-binding domains implicated in regulatory catalysis by biochemical and NMR structural approaches
  • HOMOLOGY
    Homologene
    FAMILY peptidase C19 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • regulating SIAH2 ligase stability and activity via noncatalytic ubiquitin-binding domains
  • responsible for MITF deubiquitination, utilizing a short hairpin RNA library against known deubiquitinating enzymes
  • may function differently from USP5 in cellular deubiquitination processes
  • USP13 is a AMFR-associated DUB that eliminates ubiquitin conjugates from UBL4A to maintain the functionality of BAG6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH2
  • through deubiquitination, USP13 stabilizes and upregulates MITF protein levels)
  • interacting with BECN1 (Beclin1 controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    might be a viable therapeutic target for melanoma
    ANIMAL & CELL MODELS