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FLASH GENE
Symbol USP11 contributors: shn - updated : 06-11-2016
HGNC name ubiquitin specific protease 11
HGNC id 12609
Location Xp11.23      Physical location : 47.092.313 - 47.107.726
Synonym name
  • deubiquitinating enzyme 11
  • ubiquitin carboxyl-terminal hydrolase 11
  • ubiquitin carboxyl-terminal hydrolase, X-linked
  • ubiquitin thioesterase 11
  • ubiquitin thiolesterase 11
  • ubiquitin-specific processing protease 11
  • ubiquitin-specific-processing protease 11
  • Synonym symbol(s) RP4-659F15.2, UHX1
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 15.00 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map pter - DXS1055 - DXS1003 - USP11 - DXS1208 - DXS1039 - cen
    Physical map
    FLJ20344 Xp11.3 hypothetical protein FLJ20344 RNU6P1 Xp11.3 RNA, U6 small nuclear pseudogene 1 LOC392457 X similar to Antigen KI-67 CHST7 Xp11.23 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 SLC9A7 Xp11.4-p11.1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 7 RP2 Xp11.23 retinitis pigmentosa 2 (X-linked recessive) PHF16 Xp11.3-p11.23 PHD finger protein 16 RGN Xp11.3-q11.2 regucalcin (senescence marker protein-30) RNU12 Xp11.3 RNA, U12 small nuclear P17.3 Xp11.3 neuronal protein 17.3 RBM10 Xp11.23 RNA binding motif protein 10 UBE1 Xp11.23 ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) INE1 Xp11.4-p11.3 inactivation escape 1 PCTK1 Xp11.3 PCTAIRE protein kinase 1 USP11 Xp21.2-p11.2 ubiquitin specific protease 11 ZNF157 Xp11.23 zinc finger protein 157 (HZF22) ZNF41 Xp11.23 zinc finger protein 41 LOC389850 X similar to hypothetical protein, MGC:7199 TIMP1 Xp11.23 tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ARAF1 Xp11.3-p11.23 v-raf murine sarcoma 3611 viral oncogene homolog 1 SYN1 Xp11.23 synapsin I PFC Xp11.3-p11.23 properdin P factor, complement ELK1 Xp11.3-p11.23 ELK1, member of ETS oncogene family UXT Xp11.23-p11.22 ubiquitously-expressed transcript LOC392458 X similar to spermine synthase; spermidine aminopropyltransferase LOC392459 X similar to CpG binding protein (Protein containing PHD finger and CXXC domain 1) LOC286404 Xp11.3 hypothetical gene supported by NM_006990; AB026542 LOC389851 X similar to Itchy homolog E3 ubiquitin protein ligase (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) LOC347344 Xp11.3 similar to Zinc finger protein 81 (HFZ20)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3300 - 963 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Cys box, His box, Asp and KRF domains
  • HOMOLOGY
    interspecies ortholog to Usp11, Mus musculus
    ortholog to Usp11, Rattus norvegicus
    Homologene
    FAMILY deubiquitin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text primarily localized in the nucleus of non-dividing cells
    basic FUNCTION
  • deubiquitinating enzyme controling many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction
  • USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR
  • USP11 is a critical determinant of mammary tumor initiation and progression
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RanGTP-associated protein RanBPM
  • breast cancer 2, early onse, BRCA2
  • Polycomb repressive complex 1, PRC1; melanoma nuclear protein 18, MEL18; BMI1 polycomb ring finger oncogene, BMI1
  • USP11 is an interactor of SMAD7, enhances TGFB1 signalling and can override the negative effects of SMAD7
  • USP11 is a functional interactor of RNF4, and USP11 can deubiquitinate hybrid SUMO-ubiquitin chains to counteract RNF4
  • USP11 is a unique deubiquitylation enzyme for gammaH2AX
  • XIAP is a target for USP11 and stabilization of XIAP due to its deubiquitylation by USP11 leads to the inhibition of cell anoikis and apoptosis, which in turn promotes tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    USP11 depletion results in inhibition of TGFB1-induced epithelial to mesenchymal transition
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS