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FLASH GENE
Symbol USP10 contributors: mct/pgu - updated : 19-02-2019
HGNC name ubiquitin specific protease 10
HGNC id 12608
Location 16q24.1      Physical location : 84.733.554 - 84.813.525
Synonym name
  • ubiquitin carboxyl-terminal hydrolase family 2
  • ubiquitin carboxyl-terminal hydrolase 10
  • ubiquitin thioesterase 10
  • Synonym symbol(s) UBPO, KIAA0190, MGC2621
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 79.97 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein LOC123855 16q24.1 similar to ENSANGP00000013733 MGC22001 16q24.1 hypothetical protein MGC22001 LOC388303 16 LOC388303 LOC388304 16 LOC388304 KIAA0182 16q24 LOC388304 Pfs2 16q24.1 DNA replication complex GINS protein PSF2 NOC4 16q24.3 neighbor of COX4 COX4I1 16q24.2 cytochrome c oxidase subunit IV isoform 1 LOC390744 16 similar to ribosomal protein L10a ICSBP1 16q24.1 interferon consensus sequence binding protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3399 - 798 - 2007 17004105
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Digestiveesophagus   highly
     mouthtongue  highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines melanoma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Usp10 (85.0pc)
    homolog to murine Usp10 (84.1pc)
    intraspecies paralog to ubiquitin specific protein proteases ubp
    Homologene
    FAMILY
  • deubiquitin family
  • peptidase family C19
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    basic FUNCTION
  • ubiquitin specific protease, hydrolyzing isopeptide bonds between UB and folded protein domains such as additional UB moietis or target proteins
  • cofactor that binds to the AR and stimulates the androgen response of target promoters (underlining the role of the ubiquitin/proteasome system in modulating the AR function)
  • deubiquitinating TP53, reversing MDM2-induced nuclear export and degradation
  • regulates the deubiquitination of CFTR and its trafficking in the post-endocytic compartment
  • H2AFZ and USP10 are each required for transcriptional activation of the androgen receptor (AR)-regulated KLK3 gene
  • USP10 deubiquitylates the histone variant H2AFZ and both are required for androgen receptor-mediated gene activation
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • USP10/G3BP complex
  • part of DNA-bound androgen receptor (AR) complexes
  • TANK formed a complex with ZC3H12A and a deubiquitinase, USP10, which was essential for the USP10-dependent deubiquitination of TRAF6 and the resolution of genotoxic NFKB1 activation upon DNA damage
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with G3BP to inhibit the ability of USP10 to dissassemble ubiquitin chain
  • interacting with BECN1 (Beclin1 controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities)
  • by mediating USP10-dependent deubiquitination of IKBKG, ZC3H12A induction serves as a negative feedback mechanism for attenuating genotoxic NFKB activation
  • USP10 can directly interacts with EIF4G1, while acting as a negative regulator for EIF4G1-mediated functions
  • cell & other
    REGULATION
    inhibited by a protein in the Ras-GTPase pathway
    Other translocated to the nucleus and stabilized by phosphorylation by ATM
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    by its action on TP53, may suppress tumor cell growth
    ANIMAL & CELL MODELS