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FLASH GENE
Symbol USF2 contributors: mct - updated : 15-11-2010
HGNC name upstream transcription factor 2, c-fos interacting
HGNC id 12594
Location 19q13.12      Physical location : 35.759.895 - 35.770.718
Synonym name
  • major late transcription factor 2
  • FOS-interacting protein
  • class B basic helix-loop-helix protein 12
  • Synonym symbol(s) FIP, MLTF2, bHLHb12
    DNA
    TYPE functioning gene
    STRUCTURE 10.82 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure promoter with consensus E box (CACGTG)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1732 37 346 - 2004 15276216
    9 - 1531 30.6 279 - 2004 15276216
    - - 648 29 215 prostate cancer cell lines 2004 15276216
  • missing exons 4, 5, and part of exon 6
  • can bind as a homodimer to the E-box of the cathepsin B promoter
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helix-loop-helix (HLH), leucine zipper protein
  • HOMOLOGY
    interspecies homolog to murine Usf2
    Homologene
    FAMILY
  • basix helix loop helix (bhlh) family of transcription factors
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription factor binded to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters
  • regulating expression of cathepsin B by binding to the E box element in the cathepsin B promoter as a repressor
  • serve as modulators in the induction of OSCAR and TNFSF11-mediated osteoclastogenesis
  • implicated in the progression of biliary atresia by regulation of hepcidin expression
  • activate the hepatic lipase promoter via E-box dependent and independent mechanisms
  • E-box-binding transcription factor of the basic-helix-loop-helix-leucine-zipper family, that binds to a consensus DNA sequence similar to FOXA1
  • mediates glucose-induced thrombospondin 1 expression and transforming growth factor-beta activity in mesangial cells and plays a role in diabetic nephropathy
  • one of the transcription factors that can regulate adiponutrin (PNPLA3) promoter activity in the presence of glucose
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the components of the FOXA1/androgen receptor transcriptional protein complex that contributes to the expression of androgen-regulated and prostate-specific genes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • c-fos interacting
  • binding of USF2 to prostate-specific gene promoters including the probasin promoter, spermine-binding protein promoter, and prostate-specific antigen core enhancer
  • PDX1 contributes to the transcriptional transactivation of ALX3 in pancreatic beta-cells by acting in co-ordination with USF1 and USF2 (pMID: 25040025)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    dirupted in t(6;19) with multicystic renal dysplasia (see also PUJO)
    Susceptibility to biliary atresia (BA)
    Variant & Polymorphism SNP
  • C and CC allele frequencies of rs916145 of USF2 were significantly higher in patients with BA than in healthy controls
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS