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Symbol USF1 contributors: mct/npt/pgu - updated : 04-10-2016
HGNC name upstream transcription factor 1
HGNC id 12593
Corresponding disease
FCHL1 hyperlipidemia, combined, 1
Location 1q23.3      Physical location : 161.009.041 - 161.015.757
Synonym name
  • major late transcription factor 1
  • upstream stimulatory factor 1
  • Synonym symbol(s) UEF, MLTF1, HYPLIP1, MLTF, FCHL, FCHL1, MLTFI, USF, bHLHb11
    TYPE functioning gene
    STRUCTURE 6.72 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter with consensus E box (CACGTG)
    MAPPING cloned Y linked N status provisional
    Physical map
    CD48 1q23 CD48 antigen (B-cell membrane protein) SLAMF7 1q23.1-q24.1 SLAM family member 7 LY9 1q21.3-q22 lymphocyte antigen 9 CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106 LNIR MGC33338 1q23.1 hypothetical protein MGC33338 PFDN2 1q23.1 prefoldin 2 NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 1800 - 251 - 1995 7774954
  • also called USF1/BD
  • lacks the N-terminal transactivation domain
  • localized in the nucleus and repressed the promoter activity of the angiotensinogen gene
  • plays a role as a modulator of USF1 to control the expression of target genes
  • 11 splicing 1831 - 310 - 1995 7774954
    also called USF1 wt
    Type restricted
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestine   
    Endocrinethyroid   highly
    Reproductivefemale systembreastmammary gland  
    cell lineage
    cell lines
    at STAGE
  • DNA binding protein with helix-loop-helix (HLH)
  • leucine zipper domain
  • a core motif, CACGTG, termed E box
  • mono polymer homomer , heteromer , dimer
    interspecies homolog to murine Usf1
  • basic helix-loop-helix leucine zipper family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • transcription factor binded to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters
  • regulating several genes of lipid and glucose homeostasis
  • recruits histone modification complexes and is critical for maintenance of a chromatin barrier
  • serve as modulators in the induction of OSCAR and TNFSF11-mediated osteoclastogenesis
  • activate the hepatic lipase promoter via E-box dependent and independent mechanisms
  • USF1 and NFE2 together regulate the association of Pol II with the adult beta-globin gene promoter
  • CELLULAR PROCESS nucleotide, transcription, regulation
    a component
  • USF1, PRMT1, and the histone acetyltransferases (HATs) KAT2B form a complex with both H4R3 histone methyltransferase and HAT activities
    DNA binding to the AP-1/AP-4 site on the APP promoter
    small molecule
  • physical association between USF1 and GATA1
  • interacts directly with the histone H4R3-specific methyltransferase PRMT1
  • interaction with FADS3 (FADS3 expression is modulated by USF1)
  • interact with and repress functional activities of key transcription factors involved in cellular differentiation, including USF1
  • USF1 interacts with NFE2 in erythroid cells
  • repression of USF1 transcriptional activity by HDAC9 could disrupt adipogenic differentiation
  • PDX1 contributes to the transcriptional transactivation of ALX3 in pancreatic beta-cells by acting in co-ordination with USF1 and USF2 (pMID: 25040025)
  • cell & other
    corresponding disease(s) FCHL1
    Susceptibility to diabetes and atherosclerosis
    Variant & Polymorphism SNP intronic SNP increasing the risk of diabetes and atherosclerosis (in association with APOE mutations)
    Candidate gene
    Therapy target