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FLASH GENE
Symbol UROC1 contributors: mct/npt - updated : 16-09-2009
HGNC name urocanase domain containing 1
HGNC id 26444
Corresponding disease
UROCA urocanic aciduria
Location 3q21.3      Physical location : 126.200.007 - 126.236.616
Synonym name
  • urocanase
  • imidazolonepropionate hydrolase
    • Synonym symbol(s) FLJ31300, HMFN0320, MGC135007, MGC135008
    EC.number 4.2.1.49
    DNA
    TYPE functioning gene
    STRUCTURE 36.47 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3127 - 676 - Yamada (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • urocanase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the next step: urocanic acid to formininoglutamic acid
  • participates in the synthesis of folate metabolites through histidine catabolic pathway (Espinos (2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    histidine pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • urocanase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzes the next step: urocanic acid to formininoglutamic acid
  • participates in the synthesis of folate metabolites through histidine catabolic pathway (Espinos (2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    histidine pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UROCA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS