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FLASH GENE
Symbol URM1 contributors: mct/np/pgu - updated : 04-05-2016
HGNC name ubiquitin related modifier 1 homolog (S. cerevisiae)
HGNC id 28378
Location 9q34.13      Physical location : 131.133.597 - 131.153.015
Synonym name
  • chromosome 9 open reading frame 74
  • ubiquitin related modifier 1 homolog
  • Synonym symbol(s) MGC2668, C9orf74, RP11-339B21.4
    DNA
    TYPE functioning gene
    STRUCTURE 19.42 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4369 - 63 - -
    5 - 1348 11 101 - 2008 19017811
    4 - 1745 - 146 - 2008 19017811
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta    
    Reproductivefemale systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a thiocarboxylated C-terminal glycine, involved in oxidant-induced urmylation , a highly conserved C-terminal double glycine motif, and extension of the C terminus with an additional glycine of MOCS2 and URM1 altered the localization of MOCS3 from the cytosol to the nucleus
  • first step of activation of both MOCS2 and URM1 consists of the formation of an acyl-adenylate group at the C-terminal glycine residue
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY URM1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • dual localization in the cytoplasm and the nucleus
  • basic FUNCTION
  • conserved ubiquitin-related modifier
  • acts as a sulphur carrier in the process of eukaryotic transfer RNA (tRNA) modification, providing a possible evolutionary link between ubiquitin-like proteins and sulphur transfer
  • thiolation function is critical to regulate cellular responses to nutrient starvation and oxidative stress conditions, most likely by increasing translation fidelity
  • has a conserved dual role by integrating the functions of prokaryotic sulfur carriers with those of eukaryotic protein modifiers of the Ub family
  • serves as a sulfur donor in tRNA thiolation and functions as a posttranslational modifier under conditions of oxidative stress
  • important role for URM1 modification in the response of cells to oxidative damage
  • acts as a sulfur carrier in the thiolation of eukaryotic tRNA via a mechanism that requires the formation of a thiocarboxylated URM1
  • dual roles in protein urmylation and tRNA thiolation pathways
  • ubiquitin-like molecule (UBL) with the dual capacity to act both as a sulphur carrier and posttranslational protein modifier
  • URM1 and MOCS3 function together to induce protein urmylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MOCS3 forms heterotetrameric complexes with both URM1 and MOCS2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the thiouridylases CTU1
  • cell & other
    REGULATION
    activated by by an unusual mechanism to yield a thiocarboxylate intermediate that serves as sulfur donor in tRNA thiolation reactions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS