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FLASH GENE
Symbol URI1 contributors: mct - updated : 27-10-2011
HGNC name URI1, prefoldin-like chaperone
HGNC id 13236
Location 19q12      Physical location : -
Genatlas name RNA polymerase II subunit 5-mediating protein
Synonym name
  • RPB5-mediating protein
  • RNA polymerase II, subunit 5-mediating protein
  • unconventional prefoldin RPB5 interactor
  • chromosome 19 open reading frame 2
  • Synonym symbol(s) RMP, NNX3, FLJ10575, URI, C19orf2, PPP1R19
    DNA
    TYPE functioning gene
    STRUCTURE 73.19 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2295 - 535 - 1998 9819440
    10 splicing 2260 - 495 - 1998 9819440
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    digestivemouthgingiva   
    Reproductivefemale systemovary  highly
     female systemovary  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisualinner nuclear layer 
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualganglion cell
    cell lineage
    cell lines small cell lung carcinoma, red Sternberg cell of Hodgkin disease
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • acidic region
  • nuclear localization signal (NLS)
  • a coiled-coil (CC) domain functioning as a cytoplasmic localization signal (CLS), important for the subcellular localization
  • C potential glycosylation, myristoylation and phosphorylation sites
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Rmp-pending
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting as a corepressor of transcription by its binding to RNA polymerase II
  • participate in a nutrient-related signaling pathway that is required for gene expression
  • required to maintain genome stability by playing an important function in controlling cell cycle
  • oncogene amplified in ovarian cancer cells and is required for their survival
  • radiation-sensitive factor, and it may play essential roles in hepatocellular carcinoma (HCC)growth by affecting the proliferation and apoptosis of HCC cells
  • plays important roles in the pathways controlling apoptosis and cell cycle
  • regulator of AR transcription and is critical for antagonist (bicalutamide) action
  • potential role in modulating AR recruitment to target genes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RPBS
  • prefoldin chaperone that represents a mitochondrial substrate of RPS6KB1
  • associated with the RNA polymerase II subunit POLR2E
  • cell & other
    REGULATION
    repressed by DMAP1, which was found to bind to the CC domain of C19orf2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in ovarian cancer cell lines and human ovarian carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS