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FLASH GENE
Symbol UPRT contributors: - updated : 15-06-2007
HGNC name uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
HGNC id 28334
Location Xq13.3      Physical location : 74.493.893 - 74.524.730
Synonym symbol(s) FUR1, MGC23937
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 stomach   highly
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PRPP-binding motif region
  • uracil binding region near the C-terminal
  • HOMOLOGY
    interspecies homolog to Macaca mulatta Uprt (98 p100)
    Homologene
    FAMILY UPRTase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate, is important in the pyrimidine salvage pathway
  • attractive target for rational drug design by incorporation of prodrugs that are lethal to many parasitic organisms specifically
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine salvage pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by uracil
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS