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FLASH GENE
Symbol UPP1 contributors: - updated : 04-11-2006
HGNC name uridine phosphorylase 1
HGNC id 12576
Location 7p12.3      Physical location : 48.128.354 - 48.148.329
Synonym symbol(s) UP, UPP, UPASE, UDRPASE
EC.number 2.4.2.3
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
TENS1 7p12.3 tensin-like SH2 domain-containing 1 MGC16075 7p12.3 hypothetical protein MGC16075 PKD1L1 7p13-p12 polycystic kidney disease 1 like 1 FLJ21075 7p12.3 hypothetical protein FLJ21075 HUS1 7p13-p12 HUS1 checkpoint homolog (S. pombe) MGC33329 7p12.3 hypothetical protein MGC33329 LOC136288 7p12.3 hypothetical protein LOC136288 UPP1 7p12.3 uridine phosphorylase 1 LOC393062 7 similar to Mtr3 (mRNA transport regulator 3)-homolog; Mtr3 (mRNA transport regulator 3)-homolog (yeast) MGC16075 7p12.3 hypothetical protein MGC16075 PKD1L1 7p13-p12 polycystic kidney disease 1 like 1 FLJ21075 7p12.3 hypothetical protein FLJ21075 ABCA13 7p12.3 ATP binding cassette gene, sub-family A (ABC1), member 13 LOC393063 7 similar to 60S ribosomal protein L32 C7orf33 7q36.1 chromosome 7 open reading frame 33 LOC393064 7 similar to Huntingtin interacting protein K HUS1 7p13-p12 HUS1 checkpoint homolog (S. pombe) CUL1 7q35-q36 cullin 1 MGC33329 7p12.3 hypothetical protein MGC33329 LOC136288 7p12.3 hypothetical protein LOC136288 UPP1 7p12.3 uridine phosphorylase 1 LOC392834 7 similar to Enhancer of zeste homolog 2 (ENX-1) ABCA13 7p12.3 ATP binding cassette gene, sub-family A (ABC1), member 13 RNY5 7q36 RNA, Y5 small cytoplasmic (associated with Ro protein) ERP70 7q35 protein disulfide isomerase related protein (calcium-binding protein, intestinal-related) DKFZp762I137 7q36.1 hypothetical protein DKFZp762I137 LOC155054 7q36.1 hypothetical protein LOC155054 ZNF398 7q36.1 zinc finger protein 398 ZNF282 7q35-q36 zinc finger protein 282 LOC392669 7 hypothetical gene supported by BC028690 ZNF212 7q36.1 zinc finger protein 212 LOC392835 7 similar to KIAA1285 protein LOC392897 7 similar to GDP dissociation inhibitor isoform 2; GDI-2 LOC393065 7 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 MGC26484 7p12.3 hypothetical protein MGC26484 KIAA1285 7q36.1 hypothetical protein MGC26484 FLJ31413 7q36.1 hypothetical protein FLJ31413 LOC393066 7 similar to KIAA1285 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1796 33 310 - Watanabe
differs in the 5'UTR but encodes the same isoform
- - 1857 33 310 - Watanabe
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 stomach   highly
Endocrinepancreas   predominantly
Reproductivefemale systemovary   
 female systemplacenta  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines highly in several tumor cell lines, lowly in normal cell line
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC289801
Homologene
FAMILY PNP/UDP phosphorylase family 1
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION catalyzing the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism purine/pyrimidine
signaling
5-phospho-alpha-d- ribose 1-diphosphate biosynthesis
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
inhibited by vitamin D3, TNFA, interleukin 1 and interferon gamma
Other direct regulation of expression by p53
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in pancreatic cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • potentially useful in pancreatic tumor targeting or as tumor markers
  • ANIMAL & CELL MODELS