Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UPK2 contributors: - updated : 02-02-2008
HGNC name uroplakin 2
HGNC id 12579
Location 11q23      Physical location : 118.827.007 - 118.829.268
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinary     
 bladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lininguroepithelium  
Epithelialbarrier/lining   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer oligo
HOMOLOGY
interspecies homolog to C.elegans C42C1.3
intraspecies homolog to in a region of partial synteny to chromosome 11
Homologene
FAMILY transmembrane 4,superfamily member (TM4SF)
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • specific transmembrane protein
  • type I membrane protein
  • basic FUNCTION
  • protecting urothelial apical surface during bladder distention
  • playing an important role in regulating the assembly of the asymmetric unit membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , excretion
    text Osmoregulation and Excretion
    PATHWAY
    metabolism
    signaling
    a component terminal differentiation constituent of bladder epithelium,forming 12nm protein particles in association with other UPKs,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS