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FLASH GENE
Symbol UPK1B contributors: - updated : 26-04-2004
HGNC name uroplakin 1B
HGNC id 12578
Location 3q13.3-q21      Physical location : 118.892.424 - 118.923.999
Synonym name tetraspan
Synonym symbol(s) UPIB, UPK1
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure multiple transcription start sites in exon 1
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinary     
 bladder    
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Epithelialbarrier/lininguroepithelium  
Epithelialbarrier/lining   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to bovine uroplakin 1b
Homologene
FAMILY transmembrane 4,superfamily member (TM4SF)
CATEGORY structural protein , antigen
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
CELLULAR PROCESS cell life
cell organization/biogenesis
cell migration & motility
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component terminal differentiation constituent of bladder epithelium,forming 12nm protein particles in association with other UPKs,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS