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FLASH GENE
Symbol UNC5D contributors: mct/npt - updated : 04-10-2022
HGNC name unc-5 homolog D (C. elegans)
HGNC id 18634
Location 8p12      Physical location : 35.092.974 - 35.652.180
Synonym name
  • netrin receptor Unc5h4
  • protein unc-5 homolog D
    • Synonym symbol(s) Unc5h4, KIAA1777, PRO34692, FLJ16019
    DNA
    TYPE functioning gene
    STRUCTURE 561.07 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 9149 - 953 - 2017 28754176
    17 - 8880 - 948 - 2017 28754176
    15 - 8948 - 886 - 2017 28754176
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrinepancreas    
    Nervousbrain    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a death domain motif
  • a canonical caspase cleavage site (413-DVID-416) in its cytoplasmic region, playing an important role in the induction of apoptosis
    • HOMOLOGY
    Homologene
    FAMILY
  • dependence receptor family
  • unc-5 family
    • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having serine protease inhibitor activity, and involved in signal transduction
  • may be having a role in laminar specification of cortical cells and circuitry
  • is a newly identified transcriptional target of pro&
    • 8209;apoptotic TP53 and may also act upstream of TP53 to induce TP53&
    8209;dependent apoptosis by phosphorylation at ser&
    8209;15
  • involvement of UNC5D gene in the severe myopic anisometropia
  • UNC5A, UNC5B, UNC5C and UNC5D encode dependence receptors that regulate the apoptosis/survival balance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FLRT2 interacting with UNC5D (FLRT2/UNC5D signalling modulates cortical neuron migration)
  • PRDM8 expression was almost coincident with UNC5D expression, a marker for the late multipolar phase
  • direct transcriptional target of TP53 (amplifies TP53-dependent apoptotic response)
  • UNC5A, UNC5B, UNC5C, UNC5D and ADGRL3 can simultaneously bind to FLRT3, forming a trimeric complex, and FLRT3 may form transsynaptic complexes with both ADGRL3 and UNC5
  • UNC5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in end-stage dilated cardiomyopathy (Colak 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KCNA1 and UNC5D promoter hypermethylation holds diagnostic biomarker potential in patients with early colorectal cancer
    • Therapy target
    ANIMAL & CELL MODELS