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FLASH GENE
Symbol UNC5C contributors: mct/npt - updated : 21-03-2008
HGNC name unc-5 homolog C (C. elegans)
HGNC id 12569
Location 4q22.3      Physical location : 96.083.657 - 96.470.361
Synonym name
  • unc-5 homolog 3
  • homolog of C. elegans transmembrane receptor Unc5
  • Synonym symbol(s) UNC5H3
    DNA
    TYPE functioning gene
    STRUCTURE 380.47 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D4S3264 - D4S1557 - UNC5C - D4S2380 - D4S1045 - D4S836 - D4S1283 - D4S452 - D4S1647 - D4S421 - qter
    Authors Ackerman (98)
    Physical map
    LOC389212 4 LOC389212 LOC133083 4q22.2 similar to mitochondrial matrix processing protease, alpha subunit GRID2 4q22 glutamate receptor, ionotropic, delta 2 ATOH1 4q22 atonal homolog 1 (Drosophila) SMARCAD1 4q22-q23 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 PGDS 4q22.1-q23 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 LIM 4q22 LIM protein (similar to rat protein kinase C-binding enigma) LOC389213 4 similar to hypothetical protein FLJ33610 BMPR1B 4q23-q24 bone morphogenetic protein receptor, type IB UNC5C 4q21-q23 unc-5 homolog C (C. elegans) PDHA2 4q22-q23 pyruvate dehydrogenase (lipoamide) alpha 2 COX7A3 14 cytochrome c oxidase subunit VIIa polypeptide 3 (liver) MGC46496 4q22.3-q23 hypothetical protein MGC46496 RAP1GDS1 4q21 RAP1, GTP-GDP dissociation stimulator 1 TM4SF9 4q22.3 transmembrane 4 superfamily member 9 LOC132556 4q23 similar to Transcription factor BTF3 homolog 3 EIF4E 4q21-q25 eukaryotic translation initiation factor 4E METAP1 4q22.3 methionyl aminopeptidase 1 ADH5 4q21-q23 alcohol dehydrogenase 5 (class III), chi polypeptide ADH4 4q21-q24 alcohol dehydrogenase 4 (class II), pi polypeptide LOC359806 4q24 PCNA pseudogene p1PCNA ADH6 4q21-q25 alcohol dehydrogenase 6 (class V)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3646 - 931 - Shin (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousspinal cordanterior horn  highly
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tracttrachea   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two immunoglobulin (Ig)-like domains
  • two type 1 thrombospondin motifs
  • DEATH domain
  • ZU5 domain
  • HOMOLOGY
    interspecies homolog to C.elegans Unc5
    homolog to murine Unc5hr
    Homologene
    FAMILY
  • dependence receptor family
  • unc-5 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in cell migration during cerebellum development
  • inducing repulsion in axon guidance through its cytoplasmic tail, antagonized by NTN1 (netrin 1)
  • may be functioning to promote germ cell apoptosis in the testis
  • playing an important role in spinal accessory motor neuron development (Dillon 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NTN1 receptor
  • combination of DSCAM with DCC or UNC5C plays an important role in NTN1-mediated axon attraction or repulsion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS