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FLASH GENE
Symbol UNC5B contributors: mct/npt/pgu - updated : 28-04-2017
HGNC name unc-5 homolog B (C. elegans)
HGNC id 12568
Location 10q22.1      Physical location : 72.972.297 - 73.060.749
Synonym name
  • p53-regulated receptor for death and life
  • transmembrane receptor Unc5H2
  • Synonym symbol(s) UNC5H2, p53RDL1
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 88.45 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389977 10 similar to ribosomal protein L5; 60S ribosomal protein L5 COL13A1 10q21.2-q22.1 collagen, type XIII, alpha 1 LOC387686 10 LOC387686 H2AFY2 10q22.3 H2A histone family, member Y2 AMID 10q22.2 apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death MGC34695 10q22.2 hypothetical protein MGC34695 SARA1 10q22.2 SAR1a gene homolog 1 (S. cerevisiae) CALM2P2 10q22.2 calmodulin 2 pseudogene 2 PP 10q22.1-q22.2 pyrophosphatase (inorganic) OT7T022 10q21-q22 neuropeptide FF 1; RFamide-related peptide receptor FLJ10751 10q22.2 hypothetical protein FLJ10751 LOC221017 10q22.2 similar to chromosome 6 open reading frame 182 EIF4EBP2 10q21-q22 eukaryotic translation initiation factor 4E binding protein 2 NODAL 10q21.1-q22.2 nodal homolog (mouse) KIAA1274 10q22.1 nodal homolog (mouse) PRF1 10q22.2 perforin 1 (pore forming protein) ADAMTS14 10q21.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 C10orf27 10q22.2 chromosome 10 open reading frame 27 LOC338611 10q22.2 similar to 40S ribosomal protein S26 SGPL1 10q22 sphingosine-1-phosphate lyase 1 PCBD 10q22 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) UNC5B 10q22.2 unc-5 homolog B (C. elegans) SLC29A3 10q22.2 solute carrier family 29 (nucleoside transporters), member 3 CDH23 10q22.3 cadherin related 23 PSAP 10q22.1 prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) CHST3 10q22.1 carbohydrate (chondroitin 6) sulfotransferase 3 SPOCK2 10pter-q25.3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 CGI-18 10pter-q25.3 CGI-18 protein LOC119504 10q22.2 hypothetical protein LOC119504 RTP801 DNAJB12 10q22.3 DnaJ (Hsp40) homolog, subfamily B, member 12 CBARA1 10q22.3 calcium binding atopy-related autoantigen 1 C10orf42 10q22.2 chromosome 10 open reading frame 42
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 6874 - 934 - 2005 15729359
    17 - 4998 103.6 945 - 2005 15729359
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrinepancreas    
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systemuterus   
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two immunoglobulin domains
  • two thrombospondin type-1 motifs in its N-terminal extracellular half
  • a transmembrane domain
  • a ZU-5 domain
  • a DCC binding domain
  • a C-terminal death domain
  • HOMOLOGY
    intraspecies homolog to UNC5A
    Homologene
    FAMILY
  • unc-5 family, dependence receptor family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the chemorepulsive effect of netrin-1 on specific axons
  • functioning as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system
  • required during embryonic development for vascular patterning, suggesting that it may also contribute to postnatal and pathological angiogenesis
  • promotes angiogenesis in specific vascular beds
  • triggers cell death through the activation of the serine-threonine protein kinase DAPK1
  • in the absence of netrin-1, recruitment of PPP2CA to UNC5B allows the activation of DAPK1 via a PPP2CA-mediated dephosphorylation and this mechanism is involved in angiogenesis regulation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • the pair netrin-1/UNC5H2 may regulate cell fate by controlling the proapoptotic kinase activity of DAP-kinase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct transcriptional target of TP53, mediating TP53-induced cell death
  • netrin receptor
  • interactions with NEO1 and NTN4 (NTN4 acts as an antiangiogenic factor through binding to neogenin and recruitment of UNC5B)
  • interacting physically with the serine/threonine kinase death-associated protein kinase (DAP-kinase)
  • interacting with HLX (HLX strongly increased the transcripts for several repulsive cell-guidance proteins including UNC5B, plexin-A1, and SEMA3G)
  • was recently shown to bind FLRT3
  • negative regulation of NAA10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    diruption acts solely within the fetal-placental vasculature and one that faithfully recapitulates the structural and physiological characteristics of clinical uteroplacental insufficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS