basic FUNCTION
| serine/threonine kinase activity |
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autophagy factor that functions together with ULK2 and RBCC1 |
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play critical roles during the activation of autophagy |
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ULK1 and ULK2 are functionally redundant protein kinases required to mediate autophagy under nutrient-deprived conditions in fibroblasts |
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ULK1 and ULK2 are transcriptional targets of tumor suppressor TP53, and in response to DNA damage, are upregulated by TP53 |
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ULK1 and ULK2 may mediate part of tumor suppression activity in mammalian cells and contribute to the efficacy of genotoxic chemotherapeutic drugs |
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ULK1/2 are required in the autophagy response to amino acid deprivation but not for autophagy induced by deprivation of glucose or inhibition of glucose metabolism |
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ULK1 and ULK2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport |
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ULK1 and ULK2 both function to support autophagy activation following nutrient starvation |