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FLASH GENE
Symbol ULK2 contributors: npt/pgu - updated : 30-01-2013
HGNC name unc-51-like kinase 2 (C. elegans)
HGNC id 13480
Location 17p11.2      Physical location : 19.674.143 - 19.771.239
Genatlas name
  • uncoordinated 51-like kinase 2
  • Synonym name
  • likely ortholog of mouse unc-51 like kinase 2 (C.elegans)
  • cDNA sequence,expressed in brain, >100kDa, related to C elegans to UNC-51 kinase
  • serine/threonine-protein kinase ULK2
  • Unc-51-like kinase 2
  • autophagy-related protein 1 homolog B
  • Synonym symbol(s) KIAA0623, Unc51.2, ATG1B
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 97.10 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text all variants encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 9165 112.56 1036 - 1999 10557072
    28 - 3924 112.56 1036 - 1999 10557072
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans to UNC-51 kinase
    homolog to murine Ulk2
    intraspecies homolog to ULK1
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • APG1/unc-51/ULK1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • serine/threonine kinase activity
  • autophagy factor that functions together with ULK2 and RBCC1
  • play critical roles during the activation of autophagy
  • ULK1 and ULK2 are functionally redundant protein kinases required to mediate autophagy under nutrient-deprived conditions in fibroblasts
  • ULK1 and ULK2 are transcriptional targets of tumor suppressor TP53, and in response to DNA damage, are upregulated by TP53
  • ULK1 and ULK2 may mediate part of tumor suppression activity in mammalian cells and contribute to the efficacy of genotoxic chemotherapeutic drugs
  • ULK1/2 are required in the autophagy response to amino acid deprivation but not for autophagy induced by deprivation of glucose or inhibition of glucose metabolism
  • ULK1 and ULK2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport
  • ULK1 and ULK2 both function to support autophagy activation following nutrient starvation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    uncharacterized signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATG13 function is strictly depends on RB1CC1 binding, and has an additional function independent of ULK1/2 (
  • MSTN increased in the expression of ATG4B, ULK2, with a trend to an increase in GABARAPL1 in cells treated with myostatin compared to control treated cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith Magenis syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS