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FLASH GENE
Symbol ULBP3 contributors: mct - updated : 30-11-2012
HGNC name UL16 binding protein 3
HGNC id 14895
Location 6q25.1      Physical location : 150.385.743 - 150.390.202
Synonym name
  • retinoic acid early transcript 1N
  • NKG2D ligand 3
  • ALCAN-gamma
  • Synonym symbol(s) RAET1N, ALCAN-gamma, N2DL3, NKG2DL3
    DNA
    TYPE functioning gene
    STRUCTURE 4.46 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 735 27.8 244 - 2001 11239445
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha 1 and alpha 2 domains
  • GPI domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to ulbp1
    homolog to ulbp2
    Homologene
    FAMILY
  • MHC class I family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text glycosylphosphatidylinositol (GPI)-anchored
    basic FUNCTION
  • enhancing NK cell-mediated target recognition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • involvement of TP53 in the regulation of specific ULBP1, ULBP2, ULBP3 that enhance NK cell-mediated target recognition
  • cell & other
    REGULATION
    activated by RAS activation that upregulates the expression of ULBP1, ULBP2, ULBP3
    repressed by human CMV (HCMV), able to mediate downregulation of ULBP3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS