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FLASH GENE
Symbol ULBP2 contributors: mct - updated : 22-04-2013
HGNC name UL16 binding protein 2
HGNC id 14894
Location 6q25      Physical location : 150.263.135 - 150.270.366
Synonym name
  • ALCAN-alpha protein
  • retinoic acid early transcript 1H
  • NKG2D ligand 2
  • Synonym symbol(s) ALCAN-alpha, RAET1H, N2DL2, NKG2DL2
    DNA
    TYPE functioning gene
    STRUCTURE 7.24 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SASH1 6q24.3 a kinase (PRKA) anchor protein (gravin) 12 LOC340151 6q24.3 similar to laminin receptor 1 (ribosomal protein SA); P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA) UST 6q24.3-q25.1 uronyl-2-sulfotransferase MAP3K7IP2 6q25.1-q25.3 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 LOC340152 6q24.3 similar to hypothetical protein D730019B10 PPIL4 6q24-q25 peptidylprolyl isomerase (cyclophilin)-like 4 C6orf72 6q24.3 chromosome 6 open reading frame 72 LOC389433 6 LOC389433 KATNA1 6q25.1 katanin p60 (ATPase-containing) subunit A 1 LATS1 6q24-q25.1 LATS, large tumor suppressor, homolog 1 (Drosophila) NUP43 6q24.3 nucleoporin 43kDa PCMT1 6q22.3-q24 protein-L-isoaspartate (D-aspartate) O-methyltransferase LRP11 6q24.3 low density lipoprotein receptor-related protein 11 RAET1E 6q25 retinoic acid early transcript 1E ULBP2 6q25 UL16 binding protein 2 ULBP1 6q25 UL16 binding protein 1 LOC345829 6q24.3 similar to Transcription factor BTF3 (RNA polymerase B transcription factor 3) LOC391980 6 similar to UL16 binding protein 1; alcan-beta RAET1L 6q25 retinoic acid early transcript 1L PHBP1 6q25 prohibitin pseudogene 1 ULBP3 6q25 UL16 binding protein 3 PPP1R14C 6q24.3-q25.3 protein phosphatase 1, regulatory (inhibitor) subunit 14C RNU4P1 6q25.1 RNA, U4 small nuclear pseudogene 1 (U4/7) LOC389434 6 similar to iodotyrosine dehalogenase protein PLEKHG1 6q25.1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 FTHFSDC1 6q25.1 formyltetrahydrofolate synthetase domain containing 1 LOC391982 6 similar to ribosomal protein S12 AKAP12 6q24-q25 a kinase (PRKA) anchor protein (gravin) 12
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1362 27.2 246 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • glycosyl phosphatidylinositol (GPI) linkage to the membrane
  • alpha 1 and alpha 2 domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text glycosylphosphatidylinositol (GPI)-anchored
    basic FUNCTION
  • enhancing NK cell-mediated target recognition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • involvement of TP53 in the regulation of specific ULBP1, ULBP2, ULBP3 that enhance NK cell-mediated target recognition
  • IGF2BP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULBP2 and MICB
  • cell & other
    REGULATION
    activated by RAS activation that upregulates the expression of ULBP1, ULBP2, ULBP3
    Other ULBP2 cell surface expression is controlled differently by calcium, which adds to the increasing perception that cell surface expression ULBP2 is controlled by distinct signal transduction pathways
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer highly correlated with that of ULBP2, and high expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker soluble ULBP2 seems to be useful to identify early-stage patients with risk of B-cell chronic lymphocytic leukemia progression
    Therapy target
    ANIMAL & CELL MODELS