motifs/domains
| N-terminal ubiquitin-like domain partially overlapped by a leucine zipper domain |
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a central zinc finger of the PHD finger type, contributing to the opening and/or stabilization of dense chromocenter structures to support the recruitment of modifying enzymes, like HDAC and DNMT1, required for the replication and formation of pericentromeric heterochromatin  |
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conserved SRA (SET- and RING finger-associated) domain, involved in recognition of hemimethylated DNA |
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a C-terminal zinc finger of the ring finger type, involved in chromatin modification function with the ability to recruit EME1 following replication-associated DNA damage |
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two nuclear localization signals |
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phosphorylation sites for several kinases |
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a consensus Rb binding sequence |
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a methyl DNA binding domain, the SRA (SET and RING Associated) |
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domain, which shows strong preferential binding to hemimethylated |
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CG sites, the physiological substrate for DNMT1 |
| basic FUNCTION
| functions to maintain CpG DNA methylation patterns through DNA replication by co-localizing with the DNA methyltransferase DNMT1 at chromatin |
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involved in the regulation of topoisomerase 2 alpha gene expression |
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RNA polymerase 2 transcription factor |
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nuclear protein binding to the TOP2A gene promoter and involved in DNA replication (expression is cell cycle regulated in normal cells but stably high throughout cell cycle in various cancer cell lines) |
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involved in cell proliferation by way of methylation-mediated regulation of certain genes |
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required for maintenance of CG DNA methylation, |
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and is required for the stable association of DNMT1 with chromatin |
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facilitate the optimal processing of DNA damage, consistent with previously described models and studies of chromatin remodeling during DNA repair |
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being an E3 ligase important for the maintenance of global and local DNA methylation |
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acting as a key factor for DNMT1 maintenance methylation through recognition of a fundamental unit of epigenetic inheritance, mCpG |
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required for proper heterochromatin formation in mammalian cells |
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histone-binding protein expressed only in proliferating cells |
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may serve as a focal point of transcriptional regulation mediated by EHMT2 and other chromatin modification enzymes |
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may play a role in the DNA methylation profile inheritance as well as in the histone code inheritance |
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crucial cofactor for maintenance of DNA methylation by DNMT1, is endowed with E3 ubiquitin ligase activity |
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both DNMT1 and UHRF1 coprecipitate with ubiquitin specific peptidase 7 (USP7), a de-ubiquitinating enzyme |
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required for cell cycle progression and epigenetic regulation |
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links epigenetic regulation with DNA replication |
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its ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2 |
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