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FLASH GENE
Symbol UHMK1 contributors: shn/npt - updated : 20-06-2015
HGNC name U2AF homology motif (UHM) kinase 1
HGNC id 19683
Location 1q23.3      Physical location : 162.466.963 - 162.499.419
Synonym name
  • kinase interacting stathmin
  • kinase interacting with leukemia-associated gene (stathmin)
  • U2AF homology motif (UHM) kinase 1
  • serine/threonine-protein kinase Kist
  • Synonym symbol(s) DKFZp434C1613, FLJ23015, KIS, Kist
    EC.number 2.7.1.37, 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 32.45 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D1S2675 - D1S1679 - UHMK1 - D1S2768 - D1S2844 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 8535 - 419 - -
    8 splicing 8446 - 344 - -
    8 splicing 8194 - 345 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     intestinelarge intestinecolon lowly
     liver   moderately
    Lymphoid/Immunespleen   lowly
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in the developing nervous system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RRM (RNA recognition motif) domain
  • a N-terminal serine/threonine kinase consensus region
  • a C-terminal region with homology to U2AF65
  • conjugated
    HOMOLOGY
    interspecies homolog to Uhmk1, Mus musculus
    homolog to Uhmk1, Rattus norvegicus
    homolog to UHMK1, Pan troglodytes
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text RNA granules
    basic FUNCTION
  • acting as a protein serine/threonine kinase
  • upon serum stimulation, phosphorylating CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase
  • may be involved in trafficking and/or processing of RNA
  • involved in the regulation of protein export from nucleus
  • functionally related to microtubule dynamics and axon development
  • may have a role in the developing nervous system and the adult brain
  • phosphorylates the spliceosome assembly factor
  • SF1
  • essential for neurite outgrowth in cortical neurons, stimulates 3' untranslated region-dependent local translation in neuritic projections, a component of the molecular device modulating translation in RNA-transporting granules and may participate in RNA splicing
  • CELLULAR PROCESS cell cycle, progression
    nucleotide
    PHYSIOLOGICAL PROCESS cellular trafficking transport , neurogenesis
    text regulation of protein export from nucleus
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
  • stathmin
  • CDKN1B/p27Kip1
  • KIF3A, NonO, and eEF1A
  • UHMK1, also called KIS, double-phosphorylates both serines of the SPSP motif of SP1
  • cell & other
    REGULATION
    induced by serum growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZD9)
    Variant & Polymorphism three SNPs (rs7513662 P=0.0007, rs6427680 P=0.0252, rs6694863 P=0.015) and several haplotypes showed association (eg HAP-A, HAP-B, HAP-C permutation P=0.00005)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • a clear reduction in total neuritic length and the
  • neurite count per cell after KIS knockdown by siRNA