Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UGT8 contributors: mct/npt - updated : 10-03-2010
HGNC name UDP glycosyltransferase 8
HGNC id 12555
Location 4q26      Physical location : 115.519.610 - 115.598.202
Synonym name
  • cerebroside synthase
  • UDP-galactose ceramide galactosyltransferase
  • 2 hydroxyacylsphingosine 1 beta-galactosyltransferase precursor
  • cerebroside synthase
  • uridine diphosphate glycosyltransferase 8
  • ceramide galactosyl transferase
  • Synonym symbol(s) CGT, UGT4
    EC.number 2.4.1.45
    DNA
    TYPE functioning gene
    STRUCTURE 78.59 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • promoter functions in a cell-specific manner (Tencomnao 2004)
  • a GC-box (-267/-259) and a CRE (-697/-690) were critical for its expression (GC-box and CRE function cooperatively, and CRE regulates the cell-specific expression of UGT8 gene) (Tencomnao 2004)
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC132719 4q25-q26 similar to beta-tubulin 4Q LOC391687 4 similar to ribosomal protein S12 FLJ39370 4q26 hypothetical protein FLJ39370 PRO0971 4q26 hypothetical protein PRO0971 T2BP 4q26 TRAF2 binding protein LAK 4q26 lymphocyte alpha-kinase LOC285412 4q26 similar to Epidermal Langerhans cell protein LCP1 NEUROG2 4q25 neurogenin 2 LOC91431 4q26 prematurely terminated mRNA decay factor-like FLJ11331 4q26 hypothetical protein FLJ11331 HDCMA18P 4q26 HDCMA18P protein LOC256085 4q26 similar to Tryptophan-rich protein (Congenital heart disease 5 protein) LOC389218 4 similar to Ribosomal protein L7A CG3314-PD LOC391688 4 similar to Transcription initiation factor TFIID 105 kDa subunit (TAFII-105) (TAFII105) LOC391689 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) ANK2 4q25-q27 ankyrin 2, neuronal CAMK2D 4q25 calcium/calmodulin-dependent protein kinase (CaM kinase) II delta FLJ23548 4q26 hypothetical protein FLJ23548 UGT8 4q26 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase) NDST4 4q25-q26 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase) MRPS33P3 4q26 mitochondrial ribosomal protein S33 pseudogene 3 LOC132391 4q26 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC344978 4q26 similar to actinin, alpha 4 MGC26568 NT5C3P1 4q26 5'-nucleotidase, cytosolic III pseudogene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2898 - 541 - Tencomnao (2004)
    6 - 2906 - 541 - Tencomnao (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    NervousSchwann cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ugt8
    Homologene
    FAMILY
  • UDP glycosyltransferase family
  • UGT gene superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in synthesizing myelin membrane constituents
  • transfering galactose to ceramide
  • key enzyme in the biosynthetic pathway of galactocerebroside (GalC), the most abundant glycolipid in myelin (Tencomnao 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS