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FLASH GENE
Symbol UGT8 contributors: mct/npt - updated : 10-03-2010
HGNC name UDP glycosyltransferase 8
HGNC id 12555
Location 4q26      Physical location : 115.519.610 - 115.598.202
Synonym name
  • cerebroside synthase
  • UDP-galactose ceramide galactosyltransferase
  • 2 hydroxyacylsphingosine 1 beta-galactosyltransferase precursor
  • cerebroside synthase
  • uridine diphosphate glycosyltransferase 8
  • ceramide galactosyl transferase
  • Synonym symbol(s) CGT, UGT4
    EC.number 2.4.1.45
    DNA
    TYPE functioning gene
    STRUCTURE 78.59 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • promoter functions in a cell-specific manner (Tencomnao 2004)
  • a GC-box (-267/-259) and a CRE (-697/-690) were critical for its expression (GC-box and CRE function cooperatively, and CRE regulates the cell-specific expression of UGT8 gene) (Tencomnao 2004)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2898 - 541 - Tencomnao (2004)
    6 - 2906 - 541 - Tencomnao (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    NervousSchwann cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ugt8
    Homologene
    FAMILY
  • UDP glycosyltransferase family
  • UGT gene superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in synthesizing myelin membrane constituents
  • transfering galactose to ceramide
  • key enzyme in the biosynthetic pathway of galactocerebroside (GalC), the most abundant glycolipid in myelin (Tencomnao 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS