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FLASH GENE
Symbol UGT2B17 contributors: mct - updated : 04-04-2014
HGNC name UDP glycosyltransferase 2 family, polypeptide B17
HGNC id 12547
Location 4q13.2      Physical location : 224.704 - 69.434.245
Synonym name
  • C19-steroid-specific UDP-glucuronosyltransferase
  • Synonym symbol(s) UDPGT2B17
    EC.number 2.4.1.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 31.34 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BRDG1 4q13.1 similar to RSDK2559 FLJ10808 4q13.3 hypothetical protein FLJ10808 LOC391658 4 similar to CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-ST) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3GalIA) (ST3O) (ST3GalA LOC391659 4 similar to hypothetical protein FLJ20397 GNRHR 4q21.2 gonadotropin-releasing hormone receptor HAT 4q13.3 airway trypsin-like protease LOC339967 4q13.3 hypothetical protein LOC339967 LOC339968 4q13.3 similar to RIKEN cDNA 9930032O22 gene LOC339970 4q13.3 similar to glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A LOC389208 4 similar to RIKEN cDNA 4732406D01 gene LOC391660 4 similar to RIKEN cDNA 9930019B18 gene DKFZp686L1818 4q13.3 hypothetical protein DKFZp686L1818 LOC391661 4 similar to UDP-glucuronosyltransferase YT521 4q13.3 splicing factor YT521-B MT2P1 4p11-q21 metallothionein 2 pseudogene 1 (processed) DESC1 4q13.3 DESC1 protein UGT2B29P 4q13 UDP glycosyltransferase 2 family, polypeptide B28 pseudogene UGT2B17 4q13 UDP glycosyltransferase 2 family, polypeptide B17 LOC345378 4q13.3 similar to UDP-glucuronosyltransferase 2B15 precursor, microsomal (UDPGT) (UDPGTH-3) (HLUG4) UGT2B15 4q13.3-q21.1 UDP glycosyltransferase 2 family, polypeptide B15 UGT2B10 4q13.3 UDP glycosyltransferase 2 family, polypeptide B10 LOC391662 4 similar to UDP-glucuronosyltransferase 2B7 precursor, microsomal (UDPGT) (3,4-catechol estrogen specific) (UDPGTH-2) LOC391663 4 similar to speckle-type POZ protein FLJ21934 4q13.3 hypothetical protein FLJ21934 LOC391664 4 similar to speckle-type POZ protein UGT2B27P 4q13 UDP glycosyltransferase 2 family, polypeptide B27 pseudogene UGT2B26P 4q13 UDP glycosyltransferase 2 family, polypeptide B26 pseudogene UGT2B7 4q13 UDP glycosyltransferase 2 family, polypeptide B7 LOC391665 4 similar to UDP-glucuronosyltransferase 2A1 precursor LOC391666 4 similar to RSDK2559 UGT2B11 4q13.3 UDP glycosyltransferase 2 family, polypeptide B11 LOC391667 4 similar to RSDK2559
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2099 - 530 - 2000 10623541
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Endocrineadrenal gland    
    Reproductivefemale systembreast   
     male systemprostate   
    Skin/Tegumentskin    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an 8-amino acid signal sequence
  • three potential asparagine-linked glycosylation sites
  • a single C terminal membrane-spanning domain and
  • HOMOLOGY
    interspecies homolog to C.elegans M88.1
    intraspecies homolog to UGT2B15
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • UDP-glucuronosyltransferase ER glycoprotein subfamily 2B
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds
  • catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones
  • UGT2B15 and B17 are primary androgen-regulated genes and AR is required for both their basal expression and their androgen-regulated expression
  • may play a role in the metabolism of androgens in prostate tissue
  • sex difference in UGT2B17 gene expression and corresponding protein activity could potentially result in different levels of carcinogen detoxification or drug elimination in men versus women
  • play important roles in the glucuronidation of nicotine, cotinine, and trans-3'-hydroxycotinine (3HC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    steroid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • linked to UGT2B15
  • interacting with AR (AR is required for both its basal expression and its androgen-regulated expression)
  • cell & other
    REGULATION
    Other regulated by androgens and EGF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly increased in endometrial cancer tissues compared with matched normal endometrial tissues
    tumoral       loss of function
    of NF2, NIPSNAP1, UGT2B17, and LPIN2 genes during progression of a prostate epithelial cell line to a malignant metastatic state
    Susceptibility
  • to prostate cancer
  • to osteoporotic fractures
  • Variant & Polymorphism other
  • polymorphisms increasing the risk of prostate cancer
  • copy-number variation (CNV) associated with osteoporotic fractures
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS