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FLASH GENE
Symbol UGT2B15 contributors: mlc/npt - updated : 31-03-2012
HGNC name UDP glucuronosyltransferase 2 family, polypeptide B15
HGNC id 12546
Location 4q13.2      Physical location : 224.914 - 69.536.374
Synonym name
  • glucuronolyltransferase 2B15 precursor, microsomal
  • UDP glucuronosyltransferase 3
  • UDP glycosyltransferase 2 family, polypeptide B15
  • Synonym symbol(s) UGT2B8, UGT3, UDPGT, HLUG4, UDPGTh-3
    EC.number 2.4.1.07, 2.4.1.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 24.06 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2144 60.9 530 - Nakajima (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to UGT2B17
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • UDP glucuronosyltransferase, conjugating bile acid and involved in the catabolism of steroid hormones
  • critical enzymes for the local inactivation of androgens
  • UGT2B15 and B17 are primary androgen-regulated genes and AR is required for both their basal expression and their androgen-regulated expression
  • important enzyme involved in the metabolism of multiple endobiotics and xenobiotics
  • metabolizing mainly bisphenol A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • linked to UGT2B17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to toxicity of BPA (bisphenol A)
    Variant & Polymorphism other
  • D85Y substitution in UGT2B15 decreases enzymatic function and the polymorphic alleles of UGT2B15 are closely associated with variations in the metabolism and toxicity of BPA
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS