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FLASH GENE
Symbol UGT1A8 contributors: npt/ - updated : 18-06-2005
HGNC name UDP glycosyltransferase 1 family, polypeptide A8
HGNC id 12540
Location 2q37.1      Physical location : 234.526.290 - 234.681.945
Synonym name UDP-glucuronosyltransferase 1 family polypeptide A8s
Synonym symbol(s) UGT1H, UDPGT, UGT1A8S, GNT1, UGT1*8, UGT1-08
EC.number 2.4.1.17
DNA
TYPE functioning gene
SPECIAL FEATURE
text see UGT1A@
STRUCTURE 13.00 kb     5 Exon(s)
regulatory sequence Promoter
Binding site   HRE
text structure
  • specific promoter/first exon spliced to common exons 2 to 5
  • high promoter activity correlated with the binding of nuclear proteins (complex B) to this region
  • Xenobiotic (XRE) and antioxidant (ARE) response elements were detected in the promoters of UGT1A8, UGT1A9, and UGT1A10 (Kalthoff 2010)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2396 - 530 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver   moderately
    Urinarybladder   highly
     kidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • transfer of glucuronic acid (or other nucleotide sugars) to bilirubin
  • having a potential role in hepatic detoxification (Li 2007)
  • catalyze the glucuronidation of xenobiotics, mutagens, and reactive metabolites and thus act as indirect antioxidants (Kalthoff 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS