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FLASH GENE
Symbol UGT1A6 contributors: mct/npt - updated : 01-10-2014
HGNC name UDP glucuronosyltransferase 1 family, polypeptide A6
HGNC id 12538
Location 2q37.1      Physical location : 234.600.320 - 234.681.949
Synonym name
  • nitrophenol, simple phenolic substrats
  • phenol-metabolizing UDP-glucuronosyltransferase
  • UDP glycosyltransferase 1 family, polypeptide A6
    • Synonym symbol(s) GNT1, HLUGP, UGT1F, HLUGP1, MGC29860, UDPGT, UGT1-06, UDPGT, UDPGT 1-6, UGT1S,
    EC.number 2.4.1.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see UGT1A@
    STRUCTURE 81.63 kb     5 Exon(s)
    regulatory sequence Promoter
    text structure specific promoter/first exon spliced to common exons 2 to 5
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1691 29.5 265 - 2012 22228101
  • UGT1A6.2
  • missing a substantial portion of the highly conserved substrate-binding domain, fully encoded by the first exon
    • 5 splicing 2495 - 532 expressed in the liver, kidney and bladder tissue 2012 22228101
    UGT1A6.1
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     liver    
     mouth   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • UDP glucuronosyltransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • involved in the detoxication of phenolic compounds
  • glucuronosyltransferase activity
  • plays important roles in elimination of many xenobiotics, including drugs(
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with UGT1A1, UGT1A4, possibly by heterodimerization, and their effects on the enzymatic activities are complex depending on the isoforms and substrates (Fujiwara 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in undifferentiated cells (Siissalo 2008)
    Susceptibility
  • resistance to aspirin
  • to bladder cancer
    • Variant & Polymorphism other
  • UGT1A6*2 may confer more rapid glucuronidation of salicylic acid (Feher 2009)
  • rs17863783 may protect from bladder cancer by increasing the removal of carcinogens from bladder epithelium by the UGT1A6.1 protein
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS