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FLASH GENE
Symbol UGT1A4 contributors: KTN/npt - updated : 05/11/2008
HGNC name UDP glucuronosyltransferase 1 family, polypeptide A4
HGNC id 12536
Location 2q37      Physical location : 234.627.437 - 234.681.945
Synonym name
  • UDP glycosyltransferase 1 family, polypeptide A4
  • bilirubin-specific UDPGT isozyme 2
  • bilirubin UDP-glucuronosyltransferase isozyme 2
    • Synonym symbol(s) UDPGT, UGT1D, HUG-BR2, GNT1, UGT1, UGT1-04
    EC.number 2.4.1.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see UGT1A@
    STRUCTURE 54.51 kb     5 Exon(s)
    regulatory sequence Promoter
    text structure specific promoter/first exon spliced to common exons 2 to 5
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2374 - 534 - -
  • a 28 aa signal peptide of 3 kda
  • a 506 aa mature peptide of 57 kda
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   predominantly
     intestine   moderately
     liver   moderately
     mouth   highly
    Urinarybladder   highly
     kidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 28 aa siganl peptide of 3 kda
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ugt1a5 (76.5 pc)
    homolog to rattus Ugt1a5 (77 pc)
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    text
  • single-pass membrane protein
    • basic FUNCTION
  • being of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds
  • glucuronidating bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugating
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    glucuronidation pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by phenobarbital
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS