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FLASH GENE
Symbol UGT1A3 contributors: mct/npt - updated : 25/09/2008
HGNC name UDP glycosyltransferase 1 family, polypeptide A3
HGNC id 12535
Location 2q37      Physical location : 234.637.772 - 234.681.945
Synonym name
  • UDP-glucuronosyltransferase
  • UDP-glucuronosyltransferase 1A3
  • Synonym symbol(s) UGT1C, UGT1, GNT1, UDPGT, UGT1-03, UGT1.3
    EC.number 2.4.1.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see UGT1A@
    STRUCTURE 44.17 kb     4 Exon(s)
    regulatory sequence Promoter
    text structure specific promoter/first exon spliced to common exons 2 to 5
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2345 60.3 534 - Lankisch (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon  
     mouth   highly
    Urinarybladder    
     kidney   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five potential N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • transfer of glucuronic acid (or other nucleotide sugars) to bilirubin
  • conjugates chenodeoxycholic acid in the liver
  • catalyzes the glucuronidation of estrogens, bile acids and xenobiotics including non-steroidal anti-inflammatory drugs and lipid lowering drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulation by xenobiotic, and aryl hydrocarbon receptor
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS