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FLASH GENE
Symbol UGT1A10 contributors: mct/npt - updated : 31-05-2010
HGNC name UDP glycosyltransferase 1 family, polypeptide A10
HGNC id 12531
Location 2q37.1      Physical location : 234.545.122 - 234.681.949
Synonym name UDP-glucuronosyltransferase 1A10
Synonym symbol(s) UDPGT, UGT1J, UGT1-10, GNT1
EC.number 2.4.1.17
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text see UGT1A@
STRUCTURE 136.83 kb     5 Exon(s)
regulatory sequence Promoter
text structure
  • specific promoter/first exon spliced to common exons 2 to 5
  • high promoter activity correlated with the binding of nuclear proteins (complex B) to this region
  • Xenobiotic (XRE) and antioxidant (ARE) response elements were detected in the promoters of UGT1A8, UGT1A9, and UGT1A10 (Kalthoff 2010)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2399 - 530 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
     liver   moderately
    Urinarybladder   highly
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to UGT1A9 (93 p100)
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the transfer of glucuronic acid (or other nucleotide sugars) to bilirubin
  • catalyze the glucuronidation of xenobiotics, mutagens, and reactive metabolites and thus act as indirect antioxidants (Kalthoff 2010)
  • exhibiting glucuronidating activity against metabolites of the tobacco smoke carcinogen, benzo(a)pyrene
  • having a major role in the elimination of lipophilic chemicals by glucuronidation
  • having a potential role in hepatic detoxification (Li 2007)
  • catalyzed dopamine glucuronidation at substantial rates, yielding both dopamine-4-O-glucuronide and dopamine-3-O-glucuronide (Itšaho 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by estrogen (induction of UGT1A10 mRNA expression by E(2) might be mediated through ER, and this isoform is a novel, estrogen-regulated target gene in MCF-7) (Starlard-Davenport 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS